Review

Structure-function and biological properties of the atypical chemokine receptor D6

Cinzia Cancellieri, Nicoletta Caronni, Alessandro Vacchini, Benedetta Savino, Elena M. Borroni, Massimo Locati, Raffaella Bonecchi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The atypical chemokine receptor D6 was initially called " silent" on the basis of lack of conventional signaling events that lead to directional cell migration. It has emerged that D6 is able to bind and drive to degradative compartments most inflammatory CC chemokines and that is able to convey G-protein independent signaling events to optimize its scavenging activity. We here summarize the knowledge available today on D6 structural and signaling properties and its essential role for the control of inflammatory cells traffic and proper development of the adaptive immune response.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalMolecular Immunology
Volume55
Issue number1
DOIs
Publication statusPublished - Aug 2013

Fingerprint

CC Chemokines
Adaptive Immunity
GTP-Binding Proteins
Cell Movement
chemokine receptor D6

Keywords

  • Atypical chemokine receptors
  • Chemokines
  • GPCR
  • Inflammation

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Review : Structure-function and biological properties of the atypical chemokine receptor D6. / Cancellieri, Cinzia; Caronni, Nicoletta; Vacchini, Alessandro; Savino, Benedetta; Borroni, Elena M.; Locati, Massimo; Bonecchi, Raffaella.

In: Molecular Immunology, Vol. 55, No. 1, 08.2013, p. 87-93.

Research output: Contribution to journalArticle

Cancellieri, Cinzia ; Caronni, Nicoletta ; Vacchini, Alessandro ; Savino, Benedetta ; Borroni, Elena M. ; Locati, Massimo ; Bonecchi, Raffaella. / Review : Structure-function and biological properties of the atypical chemokine receptor D6. In: Molecular Immunology. 2013 ; Vol. 55, No. 1. pp. 87-93.
@article{b54cbff1829a4ea6bf6e831bc85ea570,
title = "Review: Structure-function and biological properties of the atypical chemokine receptor D6",
abstract = "The atypical chemokine receptor D6 was initially called {"} silent{"} on the basis of lack of conventional signaling events that lead to directional cell migration. It has emerged that D6 is able to bind and drive to degradative compartments most inflammatory CC chemokines and that is able to convey G-protein independent signaling events to optimize its scavenging activity. We here summarize the knowledge available today on D6 structural and signaling properties and its essential role for the control of inflammatory cells traffic and proper development of the adaptive immune response.",
keywords = "Atypical chemokine receptors, Chemokines, GPCR, Inflammation",
author = "Cinzia Cancellieri and Nicoletta Caronni and Alessandro Vacchini and Benedetta Savino and Borroni, {Elena M.} and Massimo Locati and Raffaella Bonecchi",
year = "2013",
month = "8",
doi = "10.1016/j.molimm.2012.08.003",
language = "English",
volume = "55",
pages = "87--93",
journal = "Molecular Immunology",
issn = "0161-5890",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Review

T2 - Structure-function and biological properties of the atypical chemokine receptor D6

AU - Cancellieri, Cinzia

AU - Caronni, Nicoletta

AU - Vacchini, Alessandro

AU - Savino, Benedetta

AU - Borroni, Elena M.

AU - Locati, Massimo

AU - Bonecchi, Raffaella

PY - 2013/8

Y1 - 2013/8

N2 - The atypical chemokine receptor D6 was initially called " silent" on the basis of lack of conventional signaling events that lead to directional cell migration. It has emerged that D6 is able to bind and drive to degradative compartments most inflammatory CC chemokines and that is able to convey G-protein independent signaling events to optimize its scavenging activity. We here summarize the knowledge available today on D6 structural and signaling properties and its essential role for the control of inflammatory cells traffic and proper development of the adaptive immune response.

AB - The atypical chemokine receptor D6 was initially called " silent" on the basis of lack of conventional signaling events that lead to directional cell migration. It has emerged that D6 is able to bind and drive to degradative compartments most inflammatory CC chemokines and that is able to convey G-protein independent signaling events to optimize its scavenging activity. We here summarize the knowledge available today on D6 structural and signaling properties and its essential role for the control of inflammatory cells traffic and proper development of the adaptive immune response.

KW - Atypical chemokine receptors

KW - Chemokines

KW - GPCR

KW - Inflammation

UR - http://www.scopus.com/inward/record.url?scp=84875600840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875600840&partnerID=8YFLogxK

U2 - 10.1016/j.molimm.2012.08.003

DO - 10.1016/j.molimm.2012.08.003

M3 - Article

VL - 55

SP - 87

EP - 93

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

IS - 1

ER -