Revised guidelines for the clinical management of Lynch syndrome (HNPCC): Recommendations by a group of European experts

Hans F A Vasen, Ignacio Blanco, Katja Aktan-Collan, Jessica P. Gopie, Angel Alonso, Stefan Aretz, Inge Bernstein, Lucio Bertario, John Burn, Gabriel Capella, Chrystelle Colas, Christoph Engel, Ian M. Frayling, Karl Heinimann Maurizio Genuardi, Frederik J. Hes, Shirley V. Hodgson, John A. Karagiannis, Fiona Lalloo, Annika Lindblom, Jukka Pekka MecklinPal Møller, Torben Myrhoj, Fokko M. Nagengast, Yann Parc, Maurizio Ponz De Leon, Laura Renkonen-Sinisalo, Julian R. Sampson, Astrid Stormorken, Rolf H. Sijmons, Sabine Tejpar, Huw J W Thomas, Nils Rahner, Juul T. Wijnen, Heikki Juhani Järvinen, Gabriela Möslein

Research output: Contribution to journalArticlepeer-review

Abstract

Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families.

Original languageEnglish
Pages (from-to)812-823
Number of pages12
JournalGut
Volume62
Issue number6
DOIs
Publication statusPublished - Jun 2013

ASJC Scopus subject areas

  • Gastroenterology

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