Revised Recommendations of the International Working Group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia

Bruce D. Cheson, John M. Bennett, Kenneth J. Kopecky, Thomas Büchner, Cheryl L. Willman, Elihu H. Estey, Charles A. Schiffer, Hartmut Doehner, Martin S. Tallman, T. Andrew Lister, Francesco LoCocco, Roel Willemze, Andrea Biondi, Wolfgang Hiddemann, Richard A. Larson, Bob Löwenberg, Miguel A. Sanz, David R. Head, Ryuzo Ohno, Clara D. Bloomfield

Research output: Contribution to journalArticlepeer-review

Abstract

An International Working Group met to revise the diagnostic and response criteria for acute myelogenous leukemia originally published in 1990, as well as to provide definitions of outcomes and reporting standards to improve interpretability of data and comparisons among trials. Since the original publication, there have been major advances in our understanding of the biology and molecular genetics of acute leukemia that are clinically relevant and warrant incorporation into response definitions. Differences from the 1990 recommendations included a category of leukemia-free state, new criteria for complete remission, including cytogenetic and molecular remissions and remission duration. Storage of viable blasts for correlative studies is important for future progress in the therapy of these disorders.

Original languageEnglish
Pages (from-to)4642-4649
Number of pages8
JournalJournal of Clinical Oncology
Volume21
Issue number24
DOIs
Publication statusPublished - Dec 15 2003

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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