TY - JOUR
T1 - Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry
T2 - What is Lennert's lymphoma nowadays?
AU - Hartmann, Sylvia
AU - Agostinelli, Claudio
AU - Klapper, Wolfram
AU - Korkolopoulou, Penelope
AU - Koch, Karoline
AU - Marafioti, Teresa
AU - Piccaluga, Pier Paolo
AU - Patsouris, Efstratios
AU - Pileri, Stefano
AU - Hansmann, Martin Leo
PY - 2011/12
Y1 - 2011/12
N2 - Aims: Lennert's lymphoma is a rare variant of peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS). The aim of this study was to further characterize this tumour. Methods and results: Historical material of 97 lymphomas with a high content of epithelioid cells, collected at the Kiel Lymph Node Registry were reviewed, by applying immunohistochemistry and current diagnostic criteria. Among all cases revised, various B-cell lymphoma entities (25 cases), Hodgkin lymphomas (21 cases) and PTCL subtypes (48 cases) could be identified. A distinctive subgroup of eight PTCLs was found that were regarded as genuine Lennert's lymphomas. These cases were characterized by mild atypia, a non-activated cytotoxic phenotype [TIA1 cytotoxic granule-associated RNA binding protein (TIA1)-positive + and granzyme B-negative], and a substantial lack of follicular T-helper (T FH) cell markers. Among the other PTCLs, including angioimmunoblastic T-cell lymphoma and PTCL NOS, many cases with positivity for more than three T FH cell-associated molecules were recorded. Conclusions: Our study shows that, according to current criteria, Lennert's lymphoma is a rare but distinctive entity among epithelioid cell-rich lymphomas, differing on grounds of morphology and immunophenotype from other PTCL subtypes. An additional finding is the broad morphological spectrum of epithelioid-cell rich PTCLs showing a T FH cell phenotype.
AB - Aims: Lennert's lymphoma is a rare variant of peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS). The aim of this study was to further characterize this tumour. Methods and results: Historical material of 97 lymphomas with a high content of epithelioid cells, collected at the Kiel Lymph Node Registry were reviewed, by applying immunohistochemistry and current diagnostic criteria. Among all cases revised, various B-cell lymphoma entities (25 cases), Hodgkin lymphomas (21 cases) and PTCL subtypes (48 cases) could be identified. A distinctive subgroup of eight PTCLs was found that were regarded as genuine Lennert's lymphomas. These cases were characterized by mild atypia, a non-activated cytotoxic phenotype [TIA1 cytotoxic granule-associated RNA binding protein (TIA1)-positive + and granzyme B-negative], and a substantial lack of follicular T-helper (T FH) cell markers. Among the other PTCLs, including angioimmunoblastic T-cell lymphoma and PTCL NOS, many cases with positivity for more than three T FH cell-associated molecules were recorded. Conclusions: Our study shows that, according to current criteria, Lennert's lymphoma is a rare but distinctive entity among epithelioid cell-rich lymphomas, differing on grounds of morphology and immunophenotype from other PTCL subtypes. An additional finding is the broad morphological spectrum of epithelioid-cell rich PTCLs showing a T FH cell phenotype.
KW - AITL
KW - Epithelioid cell-rich lymphomas
KW - Lennert's lymphoma
KW - PTCL NOS
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U2 - 10.1111/j.1365-2559.2011.04069.x
DO - 10.1111/j.1365-2559.2011.04069.x
M3 - Article
C2 - 22175897
AN - SCOPUS:84855946655
VL - 59
SP - 1173
EP - 1182
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 6
ER -