Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry: What is Lennert's lymphoma nowadays?

Sylvia Hartmann, Claudio Agostinelli, Wolfram Klapper, Penelope Korkolopoulou, Karoline Koch, Teresa Marafioti, Pier Paolo Piccaluga, Efstratios Patsouris, Stefano Pileri, Martin Leo Hansmann

Research output: Contribution to journalArticle

Abstract

Aims: Lennert's lymphoma is a rare variant of peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS). The aim of this study was to further characterize this tumour. Methods and results: Historical material of 97 lymphomas with a high content of epithelioid cells, collected at the Kiel Lymph Node Registry were reviewed, by applying immunohistochemistry and current diagnostic criteria. Among all cases revised, various B-cell lymphoma entities (25 cases), Hodgkin lymphomas (21 cases) and PTCL subtypes (48 cases) could be identified. A distinctive subgroup of eight PTCLs was found that were regarded as genuine Lennert's lymphomas. These cases were characterized by mild atypia, a non-activated cytotoxic phenotype [TIA1 cytotoxic granule-associated RNA binding protein (TIA1)-positive + and granzyme B-negative], and a substantial lack of follicular T-helper (T FH) cell markers. Among the other PTCLs, including angioimmunoblastic T-cell lymphoma and PTCL NOS, many cases with positivity for more than three T FH cell-associated molecules were recorded. Conclusions: Our study shows that, according to current criteria, Lennert's lymphoma is a rare but distinctive entity among epithelioid cell-rich lymphomas, differing on grounds of morphology and immunophenotype from other PTCL subtypes. An additional finding is the broad morphological spectrum of epithelioid-cell rich PTCLs showing a T FH cell phenotype.

Original languageEnglish
Pages (from-to)1173-1182
Number of pages10
JournalHistopathology
Volume59
Issue number6
DOIs
Publication statusPublished - Dec 2011

Keywords

  • AITL
  • Epithelioid cell-rich lymphomas
  • Lennert's lymphoma
  • PTCL NOS

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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    Hartmann, S., Agostinelli, C., Klapper, W., Korkolopoulou, P., Koch, K., Marafioti, T., Piccaluga, P. P., Patsouris, E., Pileri, S., & Hansmann, M. L. (2011). Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry: What is Lennert's lymphoma nowadays? Histopathology, 59(6), 1173-1182. https://doi.org/10.1111/j.1365-2559.2011.04069.x