Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes - Proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS

A. Porwit, A. A. Van De Loosdrecht, P. Bettelheim, L. Eidenschink Brodersen, K. Burbury, E. Cremers, M. G. Della Porta, R. Ireland, U. Johansson, S. Matarraz, K. Ogata, A. Orfao, F. Preijers, K. Psarra, D. Subirá, P. Valent, V. H J Van Der Velden, D. Wells, T. M. Westers, W. KernM. C. Béné

Research output: Contribution to journalArticlepeer-review

Abstract

Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by flow cytometry (FCM) since the publication of the World Health Organization 2008 classification of myeloid neoplasms. An international working party initiated within the European LeukemiaNet and extended to include members from Australia, Canada, Japan, Taiwan and the United States has, through several workshops, developed and subsequently published consensus recommendations. The latter deal with preanalytical precautions, and propose small and large panels, which allow evaluating immunophenotypic anomalies and calculating myelodysplasia scores. The current paper provides guidelines that strongly recommend the integration of FCM data with other diagnostic tools in the diagnostic work-up of MDS.

Original languageEnglish
Pages (from-to)1793-1798
Number of pages6
JournalLeukemia
Volume28
Issue number9
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine

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