Revisiting the relationship between blood pressure and insulin-like growth factor-1

Aletta Elisabeth Schutte, Massimo Volpe, Giuliano Tocci, Elena Conti

Research output: Contribution to journalArticlepeer-review

Abstract

Conflicting evidence exists on the relationship between blood pressure (BP) and insulin-like growth factor-1 (IGF-1). We reviewed available articles and pooled extrapolated regression coefficients for the association between BP and total IGF-1 as reported in the literature and included additional data from 912 individuals from the general population. We identified 20 studies including 11 704 subjects. We also measured total IGF-1, insulin-like binding protein-3, and BP in 912 black and white men and women from South Africa (aged 20-70 years). When plotting positive and negative weighed regression coefficients (29 data points) against IGF-1, we found a significant positive relationship (r=0.31; P

Original languageEnglish
Pages (from-to)1070-1077
Number of pages8
JournalHypertension
Volume63
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Acromegaly
  • Aging
  • Hypertension
  • Vasodilation

ASJC Scopus subject areas

  • Internal Medicine

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