Abstract
Background: Extremities are peculiar sites of origin for rhabdomyosarcomas (RMS) and are usually associated with an unfavorable outcome. Methods: The authors reviewed the clinical data on 60 patients 21 years old with limb RMS treated at the Pediatric Oncology Unit of the Istituto Nazionale Tumori of Milan, in Italy, over a 30-year period. Twelve patients had tumors arising in the hand and foot. Results: Complete tumor resection was achieved in 21 patients (but in only 1 case of hand/foot RMS); all patients received chemotherapy and 43 also had radiotherapy. The alveolar subtype was identified in 62% of cases. Half of the hand/foot cases had metastatic disease at onset. Overall survival at 5 years was 33% among the hand/foot cases and 56% for the others. Most of the relapsing cases had distant metastases. Conclusions: A particularly poor survival was observed for RMS of the hand/foot due its marked tendency to spread. Surgical resection is particularly difficult in such cases and a multimodality treatment approach seems crucial to improving their outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 321-331 |
| Number of pages | 11 |
| Journal | Pediatric Hematology and Oncology |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jul 2009 |
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Keywords
- Children and adolescents
- Extremity site
- Pediatric soft tissue sarcomas
- Rhabdomyosarcoma of extremities
- Rhabdomyosarcoma of hand and foot
ASJC Scopus subject areas
- Hematology
- Oncology
- Pediatrics, Perinatology, and Child Health
Cite this
Rhabdomyosarcoma of the extremities : A focus on tumors arising in the hand and foot. / Casanova, Michela; Meazza, Cristina; Favini, Francesca; Fiore, Marco; Morosi, Carlo; Ferrari, Andrea.
In: Pediatric Hematology and Oncology, Vol. 26, No. 5, 07.2009, p. 321-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rhabdomyosarcoma of the extremities
T2 - A focus on tumors arising in the hand and foot
AU - Casanova, Michela
AU - Meazza, Cristina
AU - Favini, Francesca
AU - Fiore, Marco
AU - Morosi, Carlo
AU - Ferrari, Andrea
PY - 2009/7
Y1 - 2009/7
N2 - Background: Extremities are peculiar sites of origin for rhabdomyosarcomas (RMS) and are usually associated with an unfavorable outcome. Methods: The authors reviewed the clinical data on 60 patients 21 years old with limb RMS treated at the Pediatric Oncology Unit of the Istituto Nazionale Tumori of Milan, in Italy, over a 30-year period. Twelve patients had tumors arising in the hand and foot. Results: Complete tumor resection was achieved in 21 patients (but in only 1 case of hand/foot RMS); all patients received chemotherapy and 43 also had radiotherapy. The alveolar subtype was identified in 62% of cases. Half of the hand/foot cases had metastatic disease at onset. Overall survival at 5 years was 33% among the hand/foot cases and 56% for the others. Most of the relapsing cases had distant metastases. Conclusions: A particularly poor survival was observed for RMS of the hand/foot due its marked tendency to spread. Surgical resection is particularly difficult in such cases and a multimodality treatment approach seems crucial to improving their outcome.
AB - Background: Extremities are peculiar sites of origin for rhabdomyosarcomas (RMS) and are usually associated with an unfavorable outcome. Methods: The authors reviewed the clinical data on 60 patients 21 years old with limb RMS treated at the Pediatric Oncology Unit of the Istituto Nazionale Tumori of Milan, in Italy, over a 30-year period. Twelve patients had tumors arising in the hand and foot. Results: Complete tumor resection was achieved in 21 patients (but in only 1 case of hand/foot RMS); all patients received chemotherapy and 43 also had radiotherapy. The alveolar subtype was identified in 62% of cases. Half of the hand/foot cases had metastatic disease at onset. Overall survival at 5 years was 33% among the hand/foot cases and 56% for the others. Most of the relapsing cases had distant metastases. Conclusions: A particularly poor survival was observed for RMS of the hand/foot due its marked tendency to spread. Surgical resection is particularly difficult in such cases and a multimodality treatment approach seems crucial to improving their outcome.
KW - Children and adolescents
KW - Extremity site
KW - Pediatric soft tissue sarcomas
KW - Rhabdomyosarcoma of extremities
KW - Rhabdomyosarcoma of hand and foot
UR - http://www.scopus.com/inward/record.url?scp=68449104638&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68449104638&partnerID=8YFLogxK
U2 - 10.1080/08880010902964367
DO - 10.1080/08880010902964367
M3 - Article
C2 - 19579078
AN - SCOPUS:68449104638
VL - 26
SP - 321
EP - 331
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
SN - 0888-0018
IS - 5
ER -