Rhabdomyosarcoma of the extremities: A focus on tumors arising in the hand and foot

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Abstract

Background: Extremities are peculiar sites of origin for rhabdomyosarcomas (RMS) and are usually associated with an unfavorable outcome. Methods: The authors reviewed the clinical data on 60 patients 21 years old with limb RMS treated at the Pediatric Oncology Unit of the Istituto Nazionale Tumori of Milan, in Italy, over a 30-year period. Twelve patients had tumors arising in the hand and foot. Results: Complete tumor resection was achieved in 21 patients (but in only 1 case of hand/foot RMS); all patients received chemotherapy and 43 also had radiotherapy. The alveolar subtype was identified in 62% of cases. Half of the hand/foot cases had metastatic disease at onset. Overall survival at 5 years was 33% among the hand/foot cases and 56% for the others. Most of the relapsing cases had distant metastases. Conclusions: A particularly poor survival was observed for RMS of the hand/foot due its marked tendency to spread. Surgical resection is particularly difficult in such cases and a multimodality treatment approach seems crucial to improving their outcome.

Original languageEnglish
Pages (from-to)321-331
Number of pages11
JournalPediatric Hematology and Oncology
Volume26
Issue number5
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Rhabdomyosarcoma
Foot
Extremities
Hand
Neoplasms
Survival
Italy
Radiotherapy
Pediatrics
Neoplasm Metastasis
Drug Therapy

Keywords

  • Children and adolescents
  • Extremity site
  • Pediatric soft tissue sarcomas
  • Rhabdomyosarcoma of extremities
  • Rhabdomyosarcoma of hand and foot

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Rhabdomyosarcoma of the extremities: A focus on tumors arising in the hand and foot",
abstract = "Background: Extremities are peculiar sites of origin for rhabdomyosarcomas (RMS) and are usually associated with an unfavorable outcome. Methods: The authors reviewed the clinical data on 60 patients 21 years old with limb RMS treated at the Pediatric Oncology Unit of the Istituto Nazionale Tumori of Milan, in Italy, over a 30-year period. Twelve patients had tumors arising in the hand and foot. Results: Complete tumor resection was achieved in 21 patients (but in only 1 case of hand/foot RMS); all patients received chemotherapy and 43 also had radiotherapy. The alveolar subtype was identified in 62{\%} of cases. Half of the hand/foot cases had metastatic disease at onset. Overall survival at 5 years was 33{\%} among the hand/foot cases and 56{\%} for the others. Most of the relapsing cases had distant metastases. Conclusions: A particularly poor survival was observed for RMS of the hand/foot due its marked tendency to spread. Surgical resection is particularly difficult in such cases and a multimodality treatment approach seems crucial to improving their outcome.",
keywords = "Children and adolescents, Extremity site, Pediatric soft tissue sarcomas, Rhabdomyosarcoma of extremities, Rhabdomyosarcoma of hand and foot",
author = "Michela Casanova and Cristina Meazza and Francesca Favini and Marco Fiore and Carlo Morosi and Andrea Ferrari",
year = "2009",
month = "7",
doi = "10.1080/08880010902964367",
language = "English",
volume = "26",
pages = "321--331",
journal = "Pediatric Hematology and Oncology",
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TY - JOUR

T1 - Rhabdomyosarcoma of the extremities

T2 - A focus on tumors arising in the hand and foot

AU - Casanova, Michela

AU - Meazza, Cristina

AU - Favini, Francesca

AU - Fiore, Marco

AU - Morosi, Carlo

AU - Ferrari, Andrea

PY - 2009/7

Y1 - 2009/7

N2 - Background: Extremities are peculiar sites of origin for rhabdomyosarcomas (RMS) and are usually associated with an unfavorable outcome. Methods: The authors reviewed the clinical data on 60 patients 21 years old with limb RMS treated at the Pediatric Oncology Unit of the Istituto Nazionale Tumori of Milan, in Italy, over a 30-year period. Twelve patients had tumors arising in the hand and foot. Results: Complete tumor resection was achieved in 21 patients (but in only 1 case of hand/foot RMS); all patients received chemotherapy and 43 also had radiotherapy. The alveolar subtype was identified in 62% of cases. Half of the hand/foot cases had metastatic disease at onset. Overall survival at 5 years was 33% among the hand/foot cases and 56% for the others. Most of the relapsing cases had distant metastases. Conclusions: A particularly poor survival was observed for RMS of the hand/foot due its marked tendency to spread. Surgical resection is particularly difficult in such cases and a multimodality treatment approach seems crucial to improving their outcome.

AB - Background: Extremities are peculiar sites of origin for rhabdomyosarcomas (RMS) and are usually associated with an unfavorable outcome. Methods: The authors reviewed the clinical data on 60 patients 21 years old with limb RMS treated at the Pediatric Oncology Unit of the Istituto Nazionale Tumori of Milan, in Italy, over a 30-year period. Twelve patients had tumors arising in the hand and foot. Results: Complete tumor resection was achieved in 21 patients (but in only 1 case of hand/foot RMS); all patients received chemotherapy and 43 also had radiotherapy. The alveolar subtype was identified in 62% of cases. Half of the hand/foot cases had metastatic disease at onset. Overall survival at 5 years was 33% among the hand/foot cases and 56% for the others. Most of the relapsing cases had distant metastases. Conclusions: A particularly poor survival was observed for RMS of the hand/foot due its marked tendency to spread. Surgical resection is particularly difficult in such cases and a multimodality treatment approach seems crucial to improving their outcome.

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KW - Rhabdomyosarcoma of hand and foot

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