Rhabdomyosarcoma with primary osteolytic lesions simulating non-hodgkin's lymphoma

Franco Locatelli, Patrizia Tonani, Fulvio Porta, Marco Zecca, Giampiero Beluffi, Paola Fiori, Renato Rosso, Marco Paulli, Giuseppe Basso, Rosangela Invernizzi, Luigi Nespoli, Francesca Severi

Research output: Contribution to journalArticlepeer-review


We report the case of an 8-year-old child presenting with the pathological fracture of two vertebral bodies due to bone lytic lesions. Physical and instrumental examinations did not show any further evidence of disease. However, bone marrow aspirate showed an infiltrate of poorly differentiated cells. When the child was transferred to the Department of Pediatrics, lymphoblastic leukemia was suspected. Although the morphology of the bone marrow biopsy could have suggested a lymphoblastic lymphoma, further immunochemical and immunological studies together with the study of tissue surface antigens resulted in a diagnosis of embryonal rhabdomyosarcoma with an unusual presentation.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalPediatric Hematology and Oncology
Issue number2
Publication statusPublished - 1991


  • Osteolytic lesions
  • Rhabdomyosarcoma
  • Soft-tissue tumors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research
  • Management of Technology and Innovation


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