Rheopheresis in vascular diseases

Michele Ferrannini, G. Vischini, E. Staffolani, F. Scaccia, N. Miani, M. C. Parravano, M. M. Louis, G. Splendiani, N. Di Daniele

Research output: Contribution to journalArticle

Abstract

Background: Endothelial dysfunction is a common condition in many microvascular diseases, such as Age-related Macular Degeneration (AMD) and Peripheral Arterial Occlusive Disease (PAOD). Rheopheresis therapy improves ematic viscosity, shear stress and endothelial function while decreasing fibrinogen, LDL-cholesterol and alpha-2-macroglobulin levels. Objective: To evaluate the therapeutic efficacy of rheopheresis in patients with microcirculatory diseases. Materials and Methods: Eight patients (7 male and 1 female) were treated with rheopheresis: 3 males were affected by AMD, 4 male and 1 female by uremia and PAOD. We used Membrane Differential Filtration (MDF) with an ethinylvinylalcohol copolymer membrane as plasmafiltrator. Patients with AMD were treated once a week for ten weeks. Patients affected with PAOD were treated twice weekly for 3 weeks and then were placed on a once-a-week program. Results: In all treated patients with AMD, visual acuity improved. In all patients affected with PAOD, we observed a complete resolution of pain; 3 out of 5 had a complete remission of ulcers. There was partial reduction of ulcers in the other patients and no adverse effects were observed. Conclusion: Rheopheresis is a safe, effective form of hemorheotherapy.

Original languageEnglish
Pages (from-to)923-929
Number of pages7
JournalInternational Journal of Artificial Organs
Volume30
Issue number10
Publication statusPublished - Oct 2007

Fingerprint

Vascular Diseases
Arterial Occlusive Diseases
Peripheral Arterial Disease
Macular Degeneration
Ulcer
Membranes
alpha-Macroglobulins
Cholesterol
Uremia
LDL Cholesterol
Fibrinogen
Shear stress
Viscosity
Visual Acuity
Copolymers
Pain
Therapeutics

Keywords

  • AMD
  • Membrane differential filtration
  • PAOD
  • Rheopheresis

ASJC Scopus subject areas

  • Biophysics

Cite this

Ferrannini, M., Vischini, G., Staffolani, E., Scaccia, F., Miani, N., Parravano, M. C., ... Di Daniele, N. (2007). Rheopheresis in vascular diseases. International Journal of Artificial Organs, 30(10), 923-929.

Rheopheresis in vascular diseases. / Ferrannini, Michele; Vischini, G.; Staffolani, E.; Scaccia, F.; Miani, N.; Parravano, M. C.; Louis, M. M.; Splendiani, G.; Di Daniele, N.

In: International Journal of Artificial Organs, Vol. 30, No. 10, 10.2007, p. 923-929.

Research output: Contribution to journalArticle

Ferrannini, M, Vischini, G, Staffolani, E, Scaccia, F, Miani, N, Parravano, MC, Louis, MM, Splendiani, G & Di Daniele, N 2007, 'Rheopheresis in vascular diseases', International Journal of Artificial Organs, vol. 30, no. 10, pp. 923-929.
Ferrannini M, Vischini G, Staffolani E, Scaccia F, Miani N, Parravano MC et al. Rheopheresis in vascular diseases. International Journal of Artificial Organs. 2007 Oct;30(10):923-929.
Ferrannini, Michele ; Vischini, G. ; Staffolani, E. ; Scaccia, F. ; Miani, N. ; Parravano, M. C. ; Louis, M. M. ; Splendiani, G. ; Di Daniele, N. / Rheopheresis in vascular diseases. In: International Journal of Artificial Organs. 2007 ; Vol. 30, No. 10. pp. 923-929.
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