Abstract
Background: Endothelial dysfunction is a common condition in many microvascular diseases, such as Age-related Macular Degeneration (AMD) and Peripheral Arterial Occlusive Disease (PAOD). Rheopheresis therapy improves ematic viscosity, shear stress and endothelial function while decreasing fibrinogen, LDL-cholesterol and alpha-2-macroglobulin levels. Objective: To evaluate the therapeutic efficacy of rheopheresis in patients with microcirculatory diseases. Materials and Methods: Eight patients (7 male and 1 female) were treated with rheopheresis: 3 males were affected by AMD, 4 male and 1 female by uremia and PAOD. We used Membrane Differential Filtration (MDF) with an ethinylvinylalcohol copolymer membrane as plasmafiltrator. Patients with AMD were treated once a week for ten weeks. Patients affected with PAOD were treated twice weekly for 3 weeks and then were placed on a once-a-week program. Results: In all treated patients with AMD, visual acuity improved. In all patients affected with PAOD, we observed a complete resolution of pain; 3 out of 5 had a complete remission of ulcers. There was partial reduction of ulcers in the other patients and no adverse effects were observed. Conclusion: Rheopheresis is a safe, effective form of hemorheotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 923-929 |
| Number of pages | 7 |
| Journal | International Journal of Artificial Organs |
| Volume | 30 |
| Issue number | 10 |
| Publication status | Published - Oct 2007 |
Fingerprint
Keywords
- AMD
- Membrane differential filtration
- PAOD
- Rheopheresis
ASJC Scopus subject areas
- Biophysics
Cite this
Rheopheresis in vascular diseases. / Ferrannini, Michele; Vischini, G.; Staffolani, E.; Scaccia, F.; Miani, N.; Parravano, M. C.; Louis, M. M.; Splendiani, G.; Di Daniele, N.
In: International Journal of Artificial Organs, Vol. 30, No. 10, 10.2007, p. 923-929.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rheopheresis in vascular diseases
AU - Ferrannini, Michele
AU - Vischini, G.
AU - Staffolani, E.
AU - Scaccia, F.
AU - Miani, N.
AU - Parravano, M. C.
AU - Louis, M. M.
AU - Splendiani, G.
AU - Di Daniele, N.
PY - 2007/10
Y1 - 2007/10
N2 - Background: Endothelial dysfunction is a common condition in many microvascular diseases, such as Age-related Macular Degeneration (AMD) and Peripheral Arterial Occlusive Disease (PAOD). Rheopheresis therapy improves ematic viscosity, shear stress and endothelial function while decreasing fibrinogen, LDL-cholesterol and alpha-2-macroglobulin levels. Objective: To evaluate the therapeutic efficacy of rheopheresis in patients with microcirculatory diseases. Materials and Methods: Eight patients (7 male and 1 female) were treated with rheopheresis: 3 males were affected by AMD, 4 male and 1 female by uremia and PAOD. We used Membrane Differential Filtration (MDF) with an ethinylvinylalcohol copolymer membrane as plasmafiltrator. Patients with AMD were treated once a week for ten weeks. Patients affected with PAOD were treated twice weekly for 3 weeks and then were placed on a once-a-week program. Results: In all treated patients with AMD, visual acuity improved. In all patients affected with PAOD, we observed a complete resolution of pain; 3 out of 5 had a complete remission of ulcers. There was partial reduction of ulcers in the other patients and no adverse effects were observed. Conclusion: Rheopheresis is a safe, effective form of hemorheotherapy.
AB - Background: Endothelial dysfunction is a common condition in many microvascular diseases, such as Age-related Macular Degeneration (AMD) and Peripheral Arterial Occlusive Disease (PAOD). Rheopheresis therapy improves ematic viscosity, shear stress and endothelial function while decreasing fibrinogen, LDL-cholesterol and alpha-2-macroglobulin levels. Objective: To evaluate the therapeutic efficacy of rheopheresis in patients with microcirculatory diseases. Materials and Methods: Eight patients (7 male and 1 female) were treated with rheopheresis: 3 males were affected by AMD, 4 male and 1 female by uremia and PAOD. We used Membrane Differential Filtration (MDF) with an ethinylvinylalcohol copolymer membrane as plasmafiltrator. Patients with AMD were treated once a week for ten weeks. Patients affected with PAOD were treated twice weekly for 3 weeks and then were placed on a once-a-week program. Results: In all treated patients with AMD, visual acuity improved. In all patients affected with PAOD, we observed a complete resolution of pain; 3 out of 5 had a complete remission of ulcers. There was partial reduction of ulcers in the other patients and no adverse effects were observed. Conclusion: Rheopheresis is a safe, effective form of hemorheotherapy.
KW - AMD
KW - Membrane differential filtration
KW - PAOD
KW - Rheopheresis
UR - http://www.scopus.com/inward/record.url?scp=38149049880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38149049880&partnerID=8YFLogxK
M3 - Article
C2 - 17992654
AN - SCOPUS:38149049880
VL - 30
SP - 923
EP - 929
JO - International Journal of Artificial Organs
JF - International Journal of Artificial Organs
SN - 0391-3988
IS - 10
ER -