Abstract
Objective - To establish the frequency of connective tissue diseases (CTD) in a cohort of Italian patients with primary biliary cirrhosis (PBC) and to evaluate the availability of a marker for the early identification of the more common associated CTD. Methods - One hundred and seventy consecutive patients with histologically diagnosed PBC were screened for the presence of a CTD and/or Raynaud's phenomenon (RP). Patients were classified as having a CTD only if they fulfilled standardised criteria. Results - Forty seven patients had a CTD. The most common CTD was systemic sclerosis (SSc), found in 21 patients. RP was present in 54 patients, most of whom (n=39) had an associated CTD. The most prevalent autoantibodies included antinuclear antibodies (ANA) with anticentromere (ACA) and speckled patterns (34 and 33 patients, respectively) and extractable nuclear antigens (ENA, 27 patients). However, while the frequencies of ACA and ENA were significantly higher in patients with an associated CTD (p
| Original language | English |
|---|---|
| Pages (from-to) | 1046-1049 |
| Number of pages | 4 |
| Journal | Annals of the Rheumatic Diseases |
| Volume | 60 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Rheumatic disorders and primary biliary cirrhosis : An appraisal of 170 Italian patients. / Marasini, B.; Gagetta, M.; Rossi, V.; Ferrari, P.
In: Annals of the Rheumatic Diseases, Vol. 60, No. 11, 2001, p. 1046-1049.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rheumatic disorders and primary biliary cirrhosis
T2 - An appraisal of 170 Italian patients
AU - Marasini, B.
AU - Gagetta, M.
AU - Rossi, V.
AU - Ferrari, P.
PY - 2001
Y1 - 2001
N2 - Objective - To establish the frequency of connective tissue diseases (CTD) in a cohort of Italian patients with primary biliary cirrhosis (PBC) and to evaluate the availability of a marker for the early identification of the more common associated CTD. Methods - One hundred and seventy consecutive patients with histologically diagnosed PBC were screened for the presence of a CTD and/or Raynaud's phenomenon (RP). Patients were classified as having a CTD only if they fulfilled standardised criteria. Results - Forty seven patients had a CTD. The most common CTD was systemic sclerosis (SSc), found in 21 patients. RP was present in 54 patients, most of whom (n=39) had an associated CTD. The most prevalent autoantibodies included antinuclear antibodies (ANA) with anticentromere (ACA) and speckled patterns (34 and 33 patients, respectively) and extractable nuclear antigens (ENA, 27 patients). However, while the frequencies of ACA and ENA were significantly higher in patients with an associated CTD (p
AB - Objective - To establish the frequency of connective tissue diseases (CTD) in a cohort of Italian patients with primary biliary cirrhosis (PBC) and to evaluate the availability of a marker for the early identification of the more common associated CTD. Methods - One hundred and seventy consecutive patients with histologically diagnosed PBC were screened for the presence of a CTD and/or Raynaud's phenomenon (RP). Patients were classified as having a CTD only if they fulfilled standardised criteria. Results - Forty seven patients had a CTD. The most common CTD was systemic sclerosis (SSc), found in 21 patients. RP was present in 54 patients, most of whom (n=39) had an associated CTD. The most prevalent autoantibodies included antinuclear antibodies (ANA) with anticentromere (ACA) and speckled patterns (34 and 33 patients, respectively) and extractable nuclear antigens (ENA, 27 patients). However, while the frequencies of ACA and ENA were significantly higher in patients with an associated CTD (p
UR - http://www.scopus.com/inward/record.url?scp=0034776921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034776921&partnerID=8YFLogxK
U2 - 10.1136/ard.60.11.1046
DO - 10.1136/ard.60.11.1046
M3 - Article
C2 - 11602476
AN - SCOPUS:0034776921
VL - 60
SP - 1046
EP - 1049
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 11
ER -