Rheumatic disorders as paraneoplastic syndromes

Vito Racanelli, Marcella Prete, Carla Minoia, Elvira Favoino, Federico Perosa

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

The long-established observation that some rheumatologic disorders (RDs) are associated with - or precede - the clinical manifestations of a variety of solid and hematological tumors represents an important clue for the early diagnosis and effective treatment of the cancers. Inflammatory myopathies, seronegative rheumatoid arthritis and some atypical vasculitides are the most frequently reported paraneoplastic RDs, although paraneoplastic scleroderma- and lupus-like syndromes, erythema nodosum, and Raynaud's syndrome have also been observed. Generally, the clinical course of a paraneoplastic RD parallels that of the cancer, and surgical removal of the tumor or its medical treatment usually results in a marked regression of the clinical manifestations of the RD. Most paraneoplastic RDs are difficultly distinguishable from idiopathic RDs. Even so, some atypical features of the clinical presentation raise the suspicion of an underlying tumor. This review summarizes current hypotheses for the pathogenesis that leads a tumor to present as an RD and discusses the clinical features that help distinguish paraneoplastic from idiopathic RDs.

Original languageEnglish
Pages (from-to)352-358
Number of pages7
JournalAutoimmunity Reviews
Volume7
Issue number5
DOIs
Publication statusPublished - May 2008

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Paraneoplastic Syndromes
Neoplasms
Erythema Nodosum
Myositis
Vasculitis
Early Diagnosis
Rheumatoid Arthritis
Therapeutics

Keywords

  • Autoimmune diseases
  • Cancer
  • Paraneoplastic rheumatic syndromes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Rheumatic disorders as paraneoplastic syndromes. / Racanelli, Vito; Prete, Marcella; Minoia, Carla; Favoino, Elvira; Perosa, Federico.

In: Autoimmunity Reviews, Vol. 7, No. 5, 05.2008, p. 352-358.

Research output: Contribution to journalArticle

Racanelli, V, Prete, M, Minoia, C, Favoino, E & Perosa, F 2008, 'Rheumatic disorders as paraneoplastic syndromes', Autoimmunity Reviews, vol. 7, no. 5, pp. 352-358. https://doi.org/10.1016/j.autrev.2008.02.001
Racanelli, Vito ; Prete, Marcella ; Minoia, Carla ; Favoino, Elvira ; Perosa, Federico. / Rheumatic disorders as paraneoplastic syndromes. In: Autoimmunity Reviews. 2008 ; Vol. 7, No. 5. pp. 352-358.
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