La malattia reumatica, oggi

Translated title of the contribution: Rheumatic fever, today

Mario Carrabba, M. G. Marrazza, F. Atzeni, G. Randisi

Research output: Contribution to journalArticlepeer-review


Acute rheumatic fever (ARF), once considered the most common rheumatic disease encountered in children and adoloscents, is a rare complicance of the pharingeal infection by group A streptococci. ARF is characterized by a latency of 2-3 weeks after the acute episode of pharingitis and is characterized by at least one of the three following symptoms: 1) migratory arthritis usually of the big joints at lower limbs; 2) carditis (pericarditis, myocarditis or endomiocarditis) accompanied by the clinical and laboratory exams; 3) Sydenham chorea involving the central nervous system. Cardiac involvement presents primarily as pericarditis; endocardial or valvular involvement is rare. The carditis is approximately observed in 65% to 91% of the patients. Although, the disease prevalence is greatly reduced in the Western countries (in 1980 an annual incidence ranging from 0,23 to 1,88/100.000 inhabitants/yearly was described), actually a significant increase is being observed expecially in the developing countries (in which 2/3 of the patiens live) with an estimate incidence of 10 to 20 millions of new cases every year. The rheumatic carditis represents the worst consequence after 10 to 20 years from the first attack of rheumatic fever. The mitralic disease as stenosis or stenoinsufficiency is the most frequent form followed by the aortic valve involvement. The use of modern diagnostic instruments (Doppler echocardiography) doesn't seem to modify significantly the process of diagnostic evaluation.

Translated title of the contributionRheumatic fever, today
Original languageItalian
Pages (from-to)82-91
Number of pages10
JournalProgressi in Reumatologia
Issue number1
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Rheumatology


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