Rheumatic Manifestations in Autoimmune Liver Disease

Carlo Selmi, Carlo Selmi, Elena Generali, Merrill Eric Gershwin

Research output: Contribution to journalReview articlepeer-review


© 2017 Elsevier Inc. Autoimmune liver diseases coexist with rheumatic disorders in approximately 30% of cases and may also share pathogenic mechanisms. Autoimmune liver diseases result from an immune-mediated injury of different tissues, with autoimmune hepatitis (AIH) targeting hepatocytes, and primary biliary cholangitis (PBC) and primary sclerosing cholangitis targeting cholangiocytes. Sjogren syndrome is diagnosed in 7% of AIH cases and serologic autoimmunity profiles are a common laboratory abnormality, particularly in the case of serum antimitochondrial (PBC) or anti–liver kidney microsomal antibodies (AIH). Therapeutic strategies may overlap between rheumatic and autoimmune liver diseases and practitioners should be vigilant in managing bone loss.
Original languageEnglish
Pages (from-to)65-87
Number of pages23
JournalRheumatic Disease Clinics of North America
Issue number1
Publication statusPublished - Feb 1 2018


  • Autoantibody
  • Autoimmune comorbidity
  • Cholangitis
  • Hepatitis
  • Immune tolerance
  • Methotrexate
  • Osteoporosis
  • Personalized medicine


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