Polyarthrite rhumatoïde associée à un trait bêta-thalassémique: Aspect clinique, sérologique et immunogénétique

Translated title of the contribution: Rheumatoid arthritis in beta thalassemic trait: Clinical, serologic and immunogenetic profile

Research output: Contribution to journalArticle

Abstract

Objectives. - To investigate the clinical, serologic, radiologic and immunogenetic characteristics of rheumatoid arthritis occurring in patients with beta-thalassemic trait as compared with rheumatoid arthritis in control patients from the same geographical area. Materials and methods. - Twenty-eight patients with beta talassemic trait fulfilling the American College of Rheumatology criteria for rheumatoid arthritis were compared with a control group of twenty-eight rheumatoid arthritis patients matched for age, sex, disease duration and place of birth. Clinical and routine laboratory assessment, including anti-keratin antibodies and anti-citrullinated peptide antibodies, was carried out in the two groups. The patients were also evaluated for HLADRB1 alleles and radiologic damage. Results. - No differences were found with regard to clinical indexes of disease activity, laboratory parameters, and joint erosions. The immunogenetic analysis did not show any significant difference, the percentage of patients with alleles encoding for the shared epitope being similar in the two groups (61% vs 57%). As for the extra-articular features, we found a trend for a lower prevalence of sicca syndrome in the beta thalassemic group (14% vs 39%; P = 0.06). Rheumatoid nodules were not found in beta thalassemic patients while they were present in two rheumatoid arthritis patients in the control group. Conclusions. - The chronic polyarthritis occurring in beta thalassemic trait carriers can be regarded as a true rheumatoid arthritis similar to that found in Mediterranean countries, possibly characterized by a low prevalence of extra-articular-features.

Original languageFrench
Pages (from-to)203-207
Number of pages5
JournalRevue du Rhumatisme (Edition Francaise)
Volume71
Issue number3
DOIs
Publication statusPublished - 2004

Fingerprint

Immunogenetics
Rheumatoid Arthritis
Joints
Alleles
Rheumatoid Nodule
Control Groups
Sjogren's Syndrome
Keratins
Arthritis
Epitopes
Anti-Idiotypic Antibodies
Peptides
Antibodies

Keywords

  • Bêta-thalassemia
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

@article{c58dcc0ea5ed4fb5b6e11b415a8da730,
title = "Polyarthrite rhumato{\"i}de associ{\'e}e {\`a} un trait b{\^e}ta-thalass{\'e}mique: Aspect clinique, s{\'e}rologique et immunog{\'e}n{\'e}tique",
abstract = "Objectives. - To investigate the clinical, serologic, radiologic and immunogenetic characteristics of rheumatoid arthritis occurring in patients with beta-thalassemic trait as compared with rheumatoid arthritis in control patients from the same geographical area. Materials and methods. - Twenty-eight patients with beta talassemic trait fulfilling the American College of Rheumatology criteria for rheumatoid arthritis were compared with a control group of twenty-eight rheumatoid arthritis patients matched for age, sex, disease duration and place of birth. Clinical and routine laboratory assessment, including anti-keratin antibodies and anti-citrullinated peptide antibodies, was carried out in the two groups. The patients were also evaluated for HLADRB1 alleles and radiologic damage. Results. - No differences were found with regard to clinical indexes of disease activity, laboratory parameters, and joint erosions. The immunogenetic analysis did not show any significant difference, the percentage of patients with alleles encoding for the shared epitope being similar in the two groups (61{\%} vs 57{\%}). As for the extra-articular features, we found a trend for a lower prevalence of sicca syndrome in the beta thalassemic group (14{\%} vs 39{\%}; P = 0.06). Rheumatoid nodules were not found in beta thalassemic patients while they were present in two rheumatoid arthritis patients in the control group. Conclusions. - The chronic polyarthritis occurring in beta thalassemic trait carriers can be regarded as a true rheumatoid arthritis similar to that found in Mediterranean countries, possibly characterized by a low prevalence of extra-articular-features.",
keywords = "B{\^e}ta-thalassemia, Rheumatoid arthritis",
author = "Roberto Caporali and Serana Bugatti and Silvia Rossi and Lorenzo Cavagna and Laura Bogliolo and Carlomaurizio Montecucco",
year = "2004",
doi = "10.1016/S1169-8330(03)00153-4",
language = "Francese",
volume = "71",
pages = "203--207",
journal = "Revue du Rhumatisme (English Edition)",
issn = "0035-2659",
publisher = "Elsevier Masson",
number = "3",

}

TY - JOUR

T1 - Polyarthrite rhumatoïde associée à un trait bêta-thalassémique

T2 - Aspect clinique, sérologique et immunogénétique

AU - Caporali, Roberto

AU - Bugatti, Serana

AU - Rossi, Silvia

AU - Cavagna, Lorenzo

AU - Bogliolo, Laura

AU - Montecucco, Carlomaurizio

PY - 2004

Y1 - 2004

N2 - Objectives. - To investigate the clinical, serologic, radiologic and immunogenetic characteristics of rheumatoid arthritis occurring in patients with beta-thalassemic trait as compared with rheumatoid arthritis in control patients from the same geographical area. Materials and methods. - Twenty-eight patients with beta talassemic trait fulfilling the American College of Rheumatology criteria for rheumatoid arthritis were compared with a control group of twenty-eight rheumatoid arthritis patients matched for age, sex, disease duration and place of birth. Clinical and routine laboratory assessment, including anti-keratin antibodies and anti-citrullinated peptide antibodies, was carried out in the two groups. The patients were also evaluated for HLADRB1 alleles and radiologic damage. Results. - No differences were found with regard to clinical indexes of disease activity, laboratory parameters, and joint erosions. The immunogenetic analysis did not show any significant difference, the percentage of patients with alleles encoding for the shared epitope being similar in the two groups (61% vs 57%). As for the extra-articular features, we found a trend for a lower prevalence of sicca syndrome in the beta thalassemic group (14% vs 39%; P = 0.06). Rheumatoid nodules were not found in beta thalassemic patients while they were present in two rheumatoid arthritis patients in the control group. Conclusions. - The chronic polyarthritis occurring in beta thalassemic trait carriers can be regarded as a true rheumatoid arthritis similar to that found in Mediterranean countries, possibly characterized by a low prevalence of extra-articular-features.

AB - Objectives. - To investigate the clinical, serologic, radiologic and immunogenetic characteristics of rheumatoid arthritis occurring in patients with beta-thalassemic trait as compared with rheumatoid arthritis in control patients from the same geographical area. Materials and methods. - Twenty-eight patients with beta talassemic trait fulfilling the American College of Rheumatology criteria for rheumatoid arthritis were compared with a control group of twenty-eight rheumatoid arthritis patients matched for age, sex, disease duration and place of birth. Clinical and routine laboratory assessment, including anti-keratin antibodies and anti-citrullinated peptide antibodies, was carried out in the two groups. The patients were also evaluated for HLADRB1 alleles and radiologic damage. Results. - No differences were found with regard to clinical indexes of disease activity, laboratory parameters, and joint erosions. The immunogenetic analysis did not show any significant difference, the percentage of patients with alleles encoding for the shared epitope being similar in the two groups (61% vs 57%). As for the extra-articular features, we found a trend for a lower prevalence of sicca syndrome in the beta thalassemic group (14% vs 39%; P = 0.06). Rheumatoid nodules were not found in beta thalassemic patients while they were present in two rheumatoid arthritis patients in the control group. Conclusions. - The chronic polyarthritis occurring in beta thalassemic trait carriers can be regarded as a true rheumatoid arthritis similar to that found in Mediterranean countries, possibly characterized by a low prevalence of extra-articular-features.

KW - Bêta-thalassemia

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=15944397304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15944397304&partnerID=8YFLogxK

U2 - 10.1016/S1169-8330(03)00153-4

DO - 10.1016/S1169-8330(03)00153-4

M3 - Articolo

AN - SCOPUS:15944397304

VL - 71

SP - 203

EP - 207

JO - Revue du Rhumatisme (English Edition)

JF - Revue du Rhumatisme (English Edition)

SN - 0035-2659

IS - 3

ER -