Rheumatoid arthritis with monoclonal IgE rheumatoid factor

S. E. Burastero, G. Lo Pinto, D. Goletti, M. Cutolo, L. Burlando, P. Falagiani

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We studied a patient with rheumatoid arthritis (RA) and a high titer of IgE that could be attributed to a mono or oligoclonal expansion of IgE + B lymphocytes. These IgE had no specificity for known allergens but bound to a panel of self (including Fc fragment of IgG) and exogenous antigens, displaying properties typical of polyspecific antibodies. We concluded that (1) RA can be associated with increased amounts of polyspecific IgE antibodies; (2) clonal excess populations of B cells are not a unique feature of malignant lymphoma, but may occur in autoimmune diseases in the form of a benign oligoclonal B cell proliferation.

Original languageEnglish
Pages (from-to)489-494
Number of pages6
JournalJournal of Rheumatology
Volume20
Issue number3
Publication statusPublished - 1993

Fingerprint

Rheumatoid Factor
Immunoglobulin E
Rheumatoid Arthritis
B-Lymphocytes
Immunoglobulin Fc Fragments
Antibodies
Allergens
Autoimmune Diseases
Lymphoma
Immunoglobulin G
Cell Proliferation
Antigens
Population

Keywords

  • autoimmunity
  • B lymphocytes
  • clonality

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Burastero, S. E., Lo Pinto, G., Goletti, D., Cutolo, M., Burlando, L., & Falagiani, P. (1993). Rheumatoid arthritis with monoclonal IgE rheumatoid factor. Journal of Rheumatology, 20(3), 489-494.

Rheumatoid arthritis with monoclonal IgE rheumatoid factor. / Burastero, S. E.; Lo Pinto, G.; Goletti, D.; Cutolo, M.; Burlando, L.; Falagiani, P.

In: Journal of Rheumatology, Vol. 20, No. 3, 1993, p. 489-494.

Research output: Contribution to journalArticle

Burastero, SE, Lo Pinto, G, Goletti, D, Cutolo, M, Burlando, L & Falagiani, P 1993, 'Rheumatoid arthritis with monoclonal IgE rheumatoid factor', Journal of Rheumatology, vol. 20, no. 3, pp. 489-494.
Burastero SE, Lo Pinto G, Goletti D, Cutolo M, Burlando L, Falagiani P. Rheumatoid arthritis with monoclonal IgE rheumatoid factor. Journal of Rheumatology. 1993;20(3):489-494.
Burastero, S. E. ; Lo Pinto, G. ; Goletti, D. ; Cutolo, M. ; Burlando, L. ; Falagiani, P. / Rheumatoid arthritis with monoclonal IgE rheumatoid factor. In: Journal of Rheumatology. 1993 ; Vol. 20, No. 3. pp. 489-494.
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