Rheumatoid factor positivity rather than anti-CCP positivity, a lower disability and a lower number of anti-TNF agents failed are associated with response to rituximab in rheumatoid arthritis

Luca Quartuccio; Martina Fabris; Sara Salvin; Fabiola Atzeni; Marta Saracco; Maurizio Benucci; Marco Cimmino; Pia Morassi; Paola Masolini; Raffaele Pellerito; Maurizio Cutolo; Piercarlo Sarzi-Puttini; Salvatore De Vita

doi:10.1093/rheumatology/kep314

Rheumatoid factor positivity rather than anti-CCP positivity, a lower disability and a lower number of anti-TNF agents failed are associated with response to rituximab in rheumatoid arthritis

Luca Quartuccio, Martina Fabris, Sara Salvin, Fabiola Atzeni, Marta Saracco, Maurizio Benucci, Marco Cimmino, Pia Morassi, Paola Masolini, Raffaele Pellerito, Maurizio Cutolo, Piercarlo Sarzi-Puttini, Salvatore De Vita

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives. We explored clinical factors associated with a major response to rituximab (RTX) (e.g. ACR 550, and European League against Rheumatism (EULAR) moderate to good response) in patients with active long-standing RA and inadequate response to anti-TNF agents or traditional DMARDs. Methods. RTX was used in 110 RA patients in six different Italian centres. The mean disease activity score on 28 joints (DAS28) was 6.4±0.99 and the mean HAQ was 1.63±0.68 at baseline. Thirty-two patients (29.1%) underwent RTX after the failure of DMARD therapy, 37 (33.6%) had failed or were intolerant to at least two anti-TNF agents, and 41 (37.3%) had failed or were intolerant to one anti-TNF agent. Univariate and multivariate analyses were performed. Results. The number of previous anti-TNF agents (P=0.043), HAQ (P=0.023), RF positivity (P

Original language	English
Pages (from-to)	1557-1559
Number of pages	3
Journal	Rheumatology
Volume	48
Issue number	12
DOIs	https://doi.org/10.1093/rheumatology/kep314
Publication status	Published - 2009

Keywords

Anti-CCP
Anti-TNF
DMARDs
Rheumatoid arthritis
Rheumatoid factor
Rituximab

ASJC Scopus subject areas

Rheumatology
Pharmacology (medical)

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10.1093/rheumatology/kep314

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Quartuccio, L., Fabris, M., Salvin, S., Atzeni, F., Saracco, M., Benucci, M., Cimmino, M., Morassi, P., Masolini, P., Pellerito, R., Cutolo, M., Sarzi-Puttini, P., & De Vita, S. (2009). Rheumatoid factor positivity rather than anti-CCP positivity, a lower disability and a lower number of anti-TNF agents failed are associated with response to rituximab in rheumatoid arthritis. Rheumatology, 48(12), 1557-1559. https://doi.org/10.1093/rheumatology/kep314

Rheumatoid factor positivity rather than anti-CCP positivity, a lower disability and a lower number of anti-TNF agents failed are associated with response to rituximab in rheumatoid arthritis. / Quartuccio, Luca; Fabris, Martina; Salvin, Sara et al.

In: Rheumatology, Vol. 48, No. 12, 2009, p. 1557-1559.

Research output: Contribution to journal › Article › peer-review

Quartuccio, L, Fabris, M, Salvin, S, Atzeni, F, Saracco, M, Benucci, M, Cimmino, M, Morassi, P, Masolini, P, Pellerito, R, Cutolo, M, Sarzi-Puttini, P & De Vita, S 2009, 'Rheumatoid factor positivity rather than anti-CCP positivity, a lower disability and a lower number of anti-TNF agents failed are associated with response to rituximab in rheumatoid arthritis', Rheumatology, vol. 48, no. 12, pp. 1557-1559. https://doi.org/10.1093/rheumatology/kep314

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abstract = "Objectives. We explored clinical factors associated with a major response to rituximab (RTX) (e.g. ACR 550, and European League against Rheumatism (EULAR) moderate to good response) in patients with active long-standing RA and inadequate response to anti-TNF agents or traditional DMARDs. Methods. RTX was used in 110 RA patients in six different Italian centres. The mean disease activity score on 28 joints (DAS28) was 6.4±0.99 and the mean HAQ was 1.63±0.68 at baseline. Thirty-two patients (29.1%) underwent RTX after the failure of DMARD therapy, 37 (33.6%) had failed or were intolerant to at least two anti-TNF agents, and 41 (37.3%) had failed or were intolerant to one anti-TNF agent. Univariate and multivariate analyses were performed. Results. The number of previous anti-TNF agents (P=0.043), HAQ (P=0.023), RF positivity (P",

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AU - Quartuccio, Luca

AU - Fabris, Martina

AU - Salvin, Sara

AU - Atzeni, Fabiola

AU - Saracco, Marta

AU - Benucci, Maurizio

AU - Cimmino, Marco

AU - Morassi, Pia

AU - Masolini, Paola

AU - Pellerito, Raffaele

AU - Cutolo, Maurizio

AU - Sarzi-Puttini, Piercarlo

AU - De Vita, Salvatore

PY - 2009

Y1 - 2009

N2 - Objectives. We explored clinical factors associated with a major response to rituximab (RTX) (e.g. ACR 550, and European League against Rheumatism (EULAR) moderate to good response) in patients with active long-standing RA and inadequate response to anti-TNF agents or traditional DMARDs. Methods. RTX was used in 110 RA patients in six different Italian centres. The mean disease activity score on 28 joints (DAS28) was 6.4±0.99 and the mean HAQ was 1.63±0.68 at baseline. Thirty-two patients (29.1%) underwent RTX after the failure of DMARD therapy, 37 (33.6%) had failed or were intolerant to at least two anti-TNF agents, and 41 (37.3%) had failed or were intolerant to one anti-TNF agent. Univariate and multivariate analyses were performed. Results. The number of previous anti-TNF agents (P=0.043), HAQ (P=0.023), RF positivity (P

AB - Objectives. We explored clinical factors associated with a major response to rituximab (RTX) (e.g. ACR 550, and European League against Rheumatism (EULAR) moderate to good response) in patients with active long-standing RA and inadequate response to anti-TNF agents or traditional DMARDs. Methods. RTX was used in 110 RA patients in six different Italian centres. The mean disease activity score on 28 joints (DAS28) was 6.4±0.99 and the mean HAQ was 1.63±0.68 at baseline. Thirty-two patients (29.1%) underwent RTX after the failure of DMARD therapy, 37 (33.6%) had failed or were intolerant to at least two anti-TNF agents, and 41 (37.3%) had failed or were intolerant to one anti-TNF agent. Univariate and multivariate analyses were performed. Results. The number of previous anti-TNF agents (P=0.043), HAQ (P=0.023), RF positivity (P

KW - Anti-CCP

KW - Anti-TNF

KW - DMARDs

KW - Rheumatoid arthritis

KW - Rheumatoid factor

KW - Rituximab

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Rheumatoid factor positivity rather than anti-CCP positivity, a lower disability and a lower number of anti-TNF agents failed are associated with response to rituximab in rheumatoid arthritis

Abstract

Keywords

ASJC Scopus subject areas

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