Rheumatoid factors: Clinical applications

Francesca Ingegnoli, Roberto Castelli, Roberta Gualtierotti

Research output: Contribution to journalArticle


Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects. Rheumatoid factors form part of the workup for the differential diagnosis of arthropathies. In clinical practice, it is recommended to measure anti-cyclic citrullinated peptide antibodies and rheumatoid factors together because anti-cyclic citrullinated peptide antibodies alone are only moderately sensitive, and the combination of the two markers improves diagnostic accuracy, especially in the case of early rheumatoid arthritis. Furthermore, different rheumatoid factor isotypes alone or in combination can be helpful when managing rheumatoid arthritis patients, from the time of diagnosis until deciding on the choice of therapeutic strategy.

Original languageEnglish
Pages (from-to)727-734
Number of pages8
JournalDisease Markers
Issue number6
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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    Ingegnoli, F., Castelli, R., & Gualtierotti, R. (2013). Rheumatoid factors: Clinical applications. Disease Markers, 35(6), 727-734. https://doi.org/10.1155/2013/726598