Riboflavin and migraine

The bridge over troubled mitochondria

Bruno Colombo, Lorenzo Saraceno, Giancarlo Comi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Brain energy metabolism has been found to be disturbed in migraine. A mitochondrial defect may reduce the threshold for migraine attacks both increasing neuronal excitability and leading migrainous brain to a hyper-responsiveness to triggering stimuli. Riboflavin, a major co-factor in oxidative metabolism, may overcome this impairment. RCT studies in adult confirmed that riboflavin is safe and probably effective in migraine prophylaxis, based on level B evidence. Improving brain energy metabolism may reduce the susceptibility to migraine when brain energy demand increases due to both physiological and biopsychological factors.

Original languageEnglish
JournalNeurological Sciences
Volume35
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2014

Fingerprint

Riboflavin
Migraine Disorders
Mitochondria
Brain
Energy Metabolism

Keywords

  • Migraine
  • Mitochondria
  • Riboflavin

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)

Cite this

Riboflavin and migraine : The bridge over troubled mitochondria. / Colombo, Bruno; Saraceno, Lorenzo; Comi, Giancarlo.

In: Neurological Sciences, Vol. 35, No. SUPPL. 1, 2014.

Research output: Contribution to journalArticle

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