Riboflavin responsive multiple acyl-CoA dehydrogenase deficiency: Functional evaluation of recovery after high dose vitamin supplementation

Dionisio Peluchetti, Carlo Antozzi, Sergio Roi, Stefano DiDonato, Ferdinando Cornelio

Research output: Contribution to journalArticle


The effect of riboflavin supplementation on muscle performance and exercise metabolism was investigated in four patients with multiple acyl-coenzyme A dehydrogenase deficiency (MAD). Maximum oxygen consumption and endurance measurements were performed to assess the patients' aerobic capacity and energy metabolism during exercise. They were tested before and after treatment with pharmacological doses of riboflavin. The initially low maximum oxygen consumption and high levels of blood lactate during submaximal exercise suggest that the oxidation of both fatty acids and carbohydrates was severely impaired. All four patients experienced a dramatic improvement in aerobic performance under riboflavin supplementation.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalJournal of the Neurological Sciences
Issue number1
Publication statusPublished - 1991



  • Exercise
  • Riboflavin
  • β-Oxidation defects

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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