Riboflavin responsive multiple acyl-CoA dehydrogenase deficiency: Functional evaluation of recovery after high dose vitamin supplementation

Dionisio Peluchetti, Carlo Antozzi, Sergio Roi, Stefano DiDonato, Ferdinando Cornelio

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The effect of riboflavin supplementation on muscle performance and exercise metabolism was investigated in four patients with multiple acyl-coenzyme A dehydrogenase deficiency (MAD). Maximum oxygen consumption and endurance measurements were performed to assess the patients' aerobic capacity and energy metabolism during exercise. They were tested before and after treatment with pharmacological doses of riboflavin. The initially low maximum oxygen consumption and high levels of blood lactate during submaximal exercise suggest that the oxidation of both fatty acids and carbohydrates was severely impaired. All four patients experienced a dramatic improvement in aerobic performance under riboflavin supplementation.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalJournal of the Neurological Sciences
Volume105
Issue number1
DOIs
Publication statusPublished - 1991

Fingerprint

Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Riboflavin
Vitamins
Exercise
Oxygen Consumption
Energy Metabolism
Lactic Acid
Fatty Acids
Carbohydrates
Pharmacology
Muscles
Therapeutics

Keywords

  • Exercise
  • Riboflavin
  • β-Oxidation defects

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Riboflavin responsive multiple acyl-CoA dehydrogenase deficiency : Functional evaluation of recovery after high dose vitamin supplementation. / Peluchetti, Dionisio; Antozzi, Carlo; Roi, Sergio; DiDonato, Stefano; Cornelio, Ferdinando.

In: Journal of the Neurological Sciences, Vol. 105, No. 1, 1991, p. 93-98.

Research output: Contribution to journalArticle

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