Abstract
29 Rifamycins were tested for inhibition of Reverse Transcriptase (RT) as potential anti HIV drugs. Two purified commercial enzymes from M-MuLV and RAV-2 were used. Anti-RT activity was also measured on a crude lysate of HIV-1. The results show that some derivatives have interesting levels of activity on isolated M-MuLV and RAV-2 RTs, while they are less active on the RT in the crude HIV-1 lysate. The active derivatives include oximes and hydrazones, alkylaminoderivatives, open ansa-chain derivatives and derivatives carrying a modified nucleoside.
Original language | English |
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Pages (from-to) | 1367-1383 |
Number of pages | 17 |
Journal | Farmaco |
Volume | 47 |
Issue number | 11 |
Publication status | Published - 1992 |
ASJC Scopus subject areas
- Drug Discovery
- Pharmaceutical Science