Abstract
29 Rifamycins were tested for inhibition of Reverse Transcriptase (RT) as potential anti HIV drugs. Two purified commercial enzymes from M-MuLV and RAV-2 were used. Anti-RT activity was also measured on a crude lysate of HIV-1. The results show that some derivatives have interesting levels of activity on isolated M-MuLV and RAV-2 RTs, while they are less active on the RT in the crude HIV-1 lysate. The active derivatives include oximes and hydrazones, alkylaminoderivatives, open ansa-chain derivatives and derivatives carrying a modified nucleoside.
| Original language | English |
|---|---|
| Pages (from-to) | 1367-1383 |
| Number of pages | 17 |
| Journal | Farmaco |
| Volume | 47 |
| Issue number | 11 |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Drug Discovery
- Pharmaceutical Science
Cite this
Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1. / Bartolucci, C.; Cellai, L.; Di Filippo, P.; Segre, A.; Brufani, M.; Filocamo, L.; Bianco, A. D.; Guiso, M.; Brizzi, V.; Benedetto, A.; Di Caro, A.; Elia, G.
In: Farmaco, Vol. 47, No. 11, 1992, p. 1367-1383.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1
AU - Bartolucci, C.
AU - Cellai, L.
AU - Di Filippo, P.
AU - Segre, A.
AU - Brufani, M.
AU - Filocamo, L.
AU - Bianco, A. D.
AU - Guiso, M.
AU - Brizzi, V.
AU - Benedetto, A.
AU - Di Caro, A.
AU - Elia, G.
PY - 1992
Y1 - 1992
N2 - 29 Rifamycins were tested for inhibition of Reverse Transcriptase (RT) as potential anti HIV drugs. Two purified commercial enzymes from M-MuLV and RAV-2 were used. Anti-RT activity was also measured on a crude lysate of HIV-1. The results show that some derivatives have interesting levels of activity on isolated M-MuLV and RAV-2 RTs, while they are less active on the RT in the crude HIV-1 lysate. The active derivatives include oximes and hydrazones, alkylaminoderivatives, open ansa-chain derivatives and derivatives carrying a modified nucleoside.
AB - 29 Rifamycins were tested for inhibition of Reverse Transcriptase (RT) as potential anti HIV drugs. Two purified commercial enzymes from M-MuLV and RAV-2 were used. Anti-RT activity was also measured on a crude lysate of HIV-1. The results show that some derivatives have interesting levels of activity on isolated M-MuLV and RAV-2 RTs, while they are less active on the RT in the crude HIV-1 lysate. The active derivatives include oximes and hydrazones, alkylaminoderivatives, open ansa-chain derivatives and derivatives carrying a modified nucleoside.
UR - http://www.scopus.com/inward/record.url?scp=0027052480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027052480&partnerID=8YFLogxK
M3 - Article
C2 - 1283514
AN - SCOPUS:0027052480
VL - 47
SP - 1367
EP - 1383
JO - Farmaco
JF - Farmaco
SN - 0014-827X
IS - 11
ER -