Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1

C. Bartolucci, L. Cellai, P. Di Filippo, A. Segre, M. Brufani, L. Filocamo, A. D. Bianco, M. Guiso, V. Brizzi, A. Benedetto, A. Di Caro, G. Elia

Research output: Contribution to journalArticle

Abstract

29 Rifamycins were tested for inhibition of Reverse Transcriptase (RT) as potential anti HIV drugs. Two purified commercial enzymes from M-MuLV and RAV-2 were used. Anti-RT activity was also measured on a crude lysate of HIV-1. The results show that some derivatives have interesting levels of activity on isolated M-MuLV and RAV-2 RTs, while they are less active on the RT in the crude HIV-1 lysate. The active derivatives include oximes and hydrazones, alkylaminoderivatives, open ansa-chain derivatives and derivatives carrying a modified nucleoside.

Original languageEnglish
Pages (from-to)1367-1383
Number of pages17
JournalFarmaco
Volume47
Issue number11
Publication statusPublished - 1992

Fingerprint

Rifamycins
Reverse Transcriptase Inhibitors
RNA-Directed DNA Polymerase
HIV-1
Anti-HIV Agents
Hydrazones
Oximes
Nucleosides
Enzymes

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

Cite this

Bartolucci, C., Cellai, L., Di Filippo, P., Segre, A., Brufani, M., Filocamo, L., ... Elia, G. (1992). Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1. Farmaco, 47(11), 1367-1383.

Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1. / Bartolucci, C.; Cellai, L.; Di Filippo, P.; Segre, A.; Brufani, M.; Filocamo, L.; Bianco, A. D.; Guiso, M.; Brizzi, V.; Benedetto, A.; Di Caro, A.; Elia, G.

In: Farmaco, Vol. 47, No. 11, 1992, p. 1367-1383.

Research output: Contribution to journalArticle

Bartolucci, C, Cellai, L, Di Filippo, P, Segre, A, Brufani, M, Filocamo, L, Bianco, AD, Guiso, M, Brizzi, V, Benedetto, A, Di Caro, A & Elia, G 1992, 'Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1', Farmaco, vol. 47, no. 11, pp. 1367-1383.
Bartolucci C, Cellai L, Di Filippo P, Segre A, Brufani M, Filocamo L et al. Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1. Farmaco. 1992;47(11):1367-1383.
Bartolucci, C. ; Cellai, L. ; Di Filippo, P. ; Segre, A. ; Brufani, M. ; Filocamo, L. ; Bianco, A. D. ; Guiso, M. ; Brizzi, V. ; Benedetto, A. ; Di Caro, A. ; Elia, G. / Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1. In: Farmaco. 1992 ; Vol. 47, No. 11. pp. 1367-1383.
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AU - Segre, A.

AU - Brufani, M.

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AU - Bianco, A. D.

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