Right atrial thrombosis in two premature infants

Successful treatment with urokinase and heparin

G. Pongiglione, M. Marasini, D. Ribaldone, G. Silvestri, P. Tuo, L. Garello-Cantoni

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Vascular thrombosis is a harmful and rather frequent event in sick premature infants. Only recently has intracardiac thrombosis been described in preterm babies and virtually all the surviving cases are those treated surgically. We report the cases of two premature infants with intra-atrial thrombosis detected by cross-sectional echocardiography and successfully treated with heparin and urokinase for 12 and 16 days, respectively. Our patients required larger doses of urokinase over a longer period of time than are required at older ages to obtain thrombolysis. Our data suggest that fibrinolytic therapy may be an alternative to surgery in premature babies with right atrial thrombosis and that cross-sectional echocardiography is very useful in the titration of the therapy in order to achieve consistent dissolution of the thrombus.

Original languageEnglish
Pages (from-to)1086-1089
Number of pages4
JournalEuropean Heart Journal
Volume7
Issue number12
Publication statusPublished - 1986

Fingerprint

Thrombosis
Heparin
Echocardiography
Urokinase-Type Plasminogen Activator
Premature Infants
Titration
Surgery
Therapy
Dissolution
Thrombolysis
Therapeutics
Period of time
Thrombolytic Therapy
Dose
Blood Vessels
Alternatives
Long period

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

Cite this

Pongiglione, G., Marasini, M., Ribaldone, D., Silvestri, G., Tuo, P., & Garello-Cantoni, L. (1986). Right atrial thrombosis in two premature infants: Successful treatment with urokinase and heparin. European Heart Journal, 7(12), 1086-1089.

Right atrial thrombosis in two premature infants : Successful treatment with urokinase and heparin. / Pongiglione, G.; Marasini, M.; Ribaldone, D.; Silvestri, G.; Tuo, P.; Garello-Cantoni, L.

In: European Heart Journal, Vol. 7, No. 12, 1986, p. 1086-1089.

Research output: Contribution to journalArticle

Pongiglione, G, Marasini, M, Ribaldone, D, Silvestri, G, Tuo, P & Garello-Cantoni, L 1986, 'Right atrial thrombosis in two premature infants: Successful treatment with urokinase and heparin', European Heart Journal, vol. 7, no. 12, pp. 1086-1089.
Pongiglione, G. ; Marasini, M. ; Ribaldone, D. ; Silvestri, G. ; Tuo, P. ; Garello-Cantoni, L. / Right atrial thrombosis in two premature infants : Successful treatment with urokinase and heparin. In: European Heart Journal. 1986 ; Vol. 7, No. 12. pp. 1086-1089.
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