Right heart mechanics in untreated normotensive patients with prediabetes and type 2 diabetes mellitus: A two- and three-dimensional echocardiographic study

Marijana Tadic, Vera Celic, Cesare Cuspidi, Sanja Ilic, Biljana Pencic, Jana Radojkovic, Branislava Ivanovic, Dejana Stanisavljevic, Gonenc Kocabay, Tamara Marjanovic

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study was to determine right ventricular (RV) and right atrial (RA) deformation assessed by two-dimensional echocardiographic and three-dimensional echocardiographic (3DE) imaging in patients with prediabetes and type 2 diabetes mellitus. Methods: This cross-sectional study included 47 untreated normotensive subjects with prediabetes, 57 recently diagnosed normotensive patients with diabetes, and 54 healthy controls of similar sex and age distributions. All subjects underwent laboratory analyses and complete two-dimensional echocardiographic and 3DE examinations. Results: Three-dimensional echocardiographic RV end-diastolic volume index gradually decreased from controls across patients with diabetes to those with diabetes (69 ± 10 vs 63 ± 8 vs 58 ± 8mL/m2, P <.001), whereas 3DE RV end-systolic volume index was higher in controls compared with patients with diabetes and those with diabetes (25 ± 4 vs 23 ± 4vs 22 ± 4mL/m2, P <.001). However, there was no difference in 3DE RV ejection fraction among the three groups (63 ± 4% vs 62 ± 4% vs 61 ± 5%, P = .063). RV and RA global strain and systolic and early diastolic strain rates were decreased in patients with prediabetes and in those with diabetes compared with controls, whereas RV and RA late diastolic strain rates were increased in these patients. Multivariate regression analysis showed that RV global strain was associated with glycated hemoglobin, independent of left ventricular parameters. Conclusions: RV and RA myocardial deformation and function obtained by 3DE and two-dimensional echocardiographic strain, even in normal ranges, were decreased in patients with prediabetes and in those with diabetes compared with controls. The long-term parameter of glucose control was correlated with the right heart mechanics.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalJournal of the American Society of Echocardiography
Volume28
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Diabetes mellitus
  • Prediabetes
  • Right atrium
  • Right ventricle
  • Speckle-tracking imaging
  • Three-dimensional echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Fingerprint Dive into the research topics of 'Right heart mechanics in untreated normotensive patients with prediabetes and type 2 diabetes mellitus: A two- and three-dimensional echocardiographic study'. Together they form a unique fingerprint.

Cite this