Right heart size and function significantly correlate in patients with pulmonary arterial hypertension - A cross-sectional study 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

Lukas Fischer, Nicola Benjamin, Norbert Blank, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Maria Koegler, Hanns Martin Lorenz, Alberto M. Marra, Christian Nagel, Panagiota Xanthouli, Eduardo Bossone, Ekkehard Grünig

Research output: Contribution to journalArticle

Abstract

Background: The objective of this study was to assess, whether right atrial (RA) and ventricular (RV) size is related to RV pump function at rest and during exercise in patients with pulmonary arterial hypertension (PAH). Methods: We included 54 patients with invasively diagnosed PAH that had been stable on targeted medication. All patients underwent clinical assessments including right heart catheterization and echocardiography at rest and during exercise. RV output reserve was defined as increase of cardiac index (CI) from rest to peak exercise (ΔCIexercise). Patients were classified according to the median of RA and RV-area. RV pump function and further clinical parameters were compared between groups by student's t-test. Uni- and multivariate Pearson correlation analyses were performed. Results: Patients with larger RA and/or RV-areas (above a median of 16 and 20cm2, respectively) showed significantly lower ΔCIexercise, higher mean pulmonary arterial pressure, pulmonary vascular resistance at rest and NT-proBNP levels. Furthermore, patients with higher RV-areas presented with a significantly lower RV stroke volume and pulmonary arterial compliance at peak exercise than patients with smaller RV-size. RV area was identified as the only independent predictor of RV output reserve. Conclusion: RV and RA areas represent valuable and easily accessible indicators of RV pump function at rest and during exercise. Cardiac output reserve should be considered as an important clinical parameter. Prospective studies are needed for further evaluation.

Original languageEnglish
Article number216
JournalRespiratory Research
Volume19
Issue number1
DOIs
Publication statusPublished - Nov 8 2018

Keywords

  • Pulmonary hypertension
  • Pump function
  • Right atrial size
  • Right ventricular output reserve
  • Right ventricular size

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Fischer, L., Benjamin, N., Blank, N., Egenlauf, B., Fischer, C., Harutyunova, S., Koegler, M., Lorenz, H. M., Marra, A. M., Nagel, C., Xanthouli, P., Bossone, E., & Grünig, E. (2018). Right heart size and function significantly correlate in patients with pulmonary arterial hypertension - A cross-sectional study 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology. Respiratory Research, 19(1), [216]. https://doi.org/10.1186/s12931-018-0913-x