Right hemisphere involvement in non-fluent primary progressive aphasia

Claudia Repetto, Rosa Manenti, Maria Cotelli, Marco Calabria, Orazio Zanetti, Barbara Borroni, Alessandro Padovani, Carlo Miniussi

Research output: Contribution to journalArticlepeer-review


We described a 56-years-old man with a diagnosis of "non-fluent primary progressive aphasia" (NfPPA). An accurate neuropsychological, neurological and neuroimaging evaluation was performed in order to assess clinical and behavioural features of the patient. From a neuropsychological point of view, the patient showed a typical cognitive profile of subjects affected by NfPPA: a prominent language deficit, associated with impairments in several cognitive domains after three years from the onset of the symptomatology. The most intriguing feature is that SPECT revealed hypoperfusion in the right frontal cortex, albeit the patient is right-handed. This unexpected finding shows that NfPPA may arise not only from cortical abnormalities in the language-dominant left hemisphere, but also from right hemisphere involvement in a right hander (crossed aphasia).

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalBehavioural Neurology
Issue number4
Publication statusPublished - 2007


  • Frontotemporal dementia
  • Language disorder
  • Lateralization
  • Non-fluent primary progressive aphasia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)


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