TY - JOUR
T1 - Right Inferior Parietal Lobule Activity Is Associated With Handwriting Spontaneous Tempo
AU - Bonzano, Laura
AU - Bisio, Ambra
AU - Pedullà, Ludovico
AU - Brichetto, Giampaolo
AU - Bove, Marco
N1 - Funding Information:
Funding. This study was supported by FISM (Fondazione Italiana Sclerosi Multipla onlus) grant no. 2014/R/5.
Publisher Copyright:
© Copyright © 2021 Bonzano, Bisio, Pedullà, Brichetto and Bove.
PY - 2021/6/9
Y1 - 2021/6/9
N2 - Handwriting is a complex activity including motor planning and visuomotor integration and referring to some brain areas identified as “writing centers.” Although temporal features of handwriting are as important as spatial ones, to our knowledge, there is no evidence of the description of specific brain areas associated with handwriting tempo. People with multiple sclerosis (PwMS) show handwriting impairments that are mainly referred to as the temporal features of the task. The aim of this work was to assess differences in the brain activation pattern elicited by handwriting between PwMS and healthy controls (HC), with the final goal of identifying possible areas specific for handwriting tempo. Subjects were asked to write a sentence at their spontaneous speed. PwMS differed only in temporal handwriting features from HC and showed reduced activation with a subset of the clusters observed in HC. Spearman’s correlation analysis was performed between handwriting temporal parameters and the activity in the brain areas resulting from the contrast analysis, HC > PwMS. We found that the right inferior parietal lobule (IPL) negatively correlated with the duration of the sentence, indicating that the higher the right IPL activity, the faster the handwriting performance. We propose that the right IPL might be considered a “writing tempo center.”
AB - Handwriting is a complex activity including motor planning and visuomotor integration and referring to some brain areas identified as “writing centers.” Although temporal features of handwriting are as important as spatial ones, to our knowledge, there is no evidence of the description of specific brain areas associated with handwriting tempo. People with multiple sclerosis (PwMS) show handwriting impairments that are mainly referred to as the temporal features of the task. The aim of this work was to assess differences in the brain activation pattern elicited by handwriting between PwMS and healthy controls (HC), with the final goal of identifying possible areas specific for handwriting tempo. Subjects were asked to write a sentence at their spontaneous speed. PwMS differed only in temporal handwriting features from HC and showed reduced activation with a subset of the clusters observed in HC. Spearman’s correlation analysis was performed between handwriting temporal parameters and the activity in the brain areas resulting from the contrast analysis, HC > PwMS. We found that the right inferior parietal lobule (IPL) negatively correlated with the duration of the sentence, indicating that the higher the right IPL activity, the faster the handwriting performance. We propose that the right IPL might be considered a “writing tempo center.”
KW - functional magnetic resonance imaging
KW - handwriting
KW - inferior parietal lobule
KW - spontaneous tempo
KW - writing center
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U2 - 10.3389/fnins.2021.656856
DO - 10.3389/fnins.2021.656856
M3 - Article
AN - SCOPUS:85108426021
VL - 15
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
SN - 1662-4548
M1 - 656856
ER -