Right ventricular remodeling in idiopathic pulmonary arterial hypertension: Adaptive versus maladaptive morphology

Roberto Badagliacca, Roberto Poscia, Beatrice Pezzuto, Martina Nocioni, Mario Mezzapesa, Marco Francone, Elisa Giannetta, Silvia Papa, Cristina Gambardella, Susanna Sciomer, Maurizio Volterrani, Francesco Fedele, Carmine Dario Vizza

Research output: Contribution to journalArticle

Abstract

Background Although increased pulmonary pressure is caused by changes in the pulmonary vasculature, prognosis in idiopathic pulmonary arterial hypertension (IPAH) is strongly associated with right ventricular (RV) function. The aim of this study was to describe the best RV adaptive remodeling pattern to increased afterload in IPAH. Methods In 60 consecutive patients with IPAH, RV morphologic and functional features were evaluated by echocardiography and cardiac magnetic resonance imaging. To address the question of the best RV adaptation pattern, we divided the study population into two groups by the median value of RV mass/volume ratio (0.46) because this parameter allows the distinction between RV eccentric (≤0.46) and concentric hypertrophy (>0.46). The two groups were compared for RV remodeling and systolic function parameters, World Health Organization class, pulmonary hemodynamics, and 6-minute walk test. Results Despite similar pulmonary vascular resistance, mean pulmonary pressure, and compliance, patients with eccentric hypertrophy had advanced World Health Organization class and worse 6-minute walk test, hemodynamics, RV remodeling, and systolic function parameters compared with patients with concentric hypertrophy. The group with concentric hypertrophy had higher RV to pulmonary arterial coupling compared with the group with eccentric hypertrophy (1.24 ± 0.26 vs 0.83 ± 0.33, p = 0.0001), indicating higher RV efficiency. A significant correlation was found between pulmonary vascular resistance and RV to pulmonary arterial coupling (r = -0.55, = 0.31, p = 0.0001), with patients with RV mass/volume ratio > 0.46 at the higher part of the scatterplot, confirming more adequate RV function. Conclusions Concentric hypertrophy might represent a more favorable RV adaptive remodeling pattern to increased afterload in IPAH because it is associated with more suitable systolic function and mechanical efficiency.

Original languageEnglish
Pages (from-to)395-403
Number of pages9
JournalJournal of Heart and Lung Transplantation
Volume34
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

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Ventricular Remodeling
Hypertrophy
Lung
Right Ventricular Function
Vascular Resistance
Hemodynamics
Lung Compliance
Pressure
Patient Rights
Echocardiography
Familial Primary Pulmonary Hypertension
Magnetic Resonance Imaging
Population

Keywords

  • cardiac magnetic resonance
  • echocardiography
  • pulmonary arterial hypertension
  • right ventricle remodeling

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery
  • Medicine(all)

Cite this

Right ventricular remodeling in idiopathic pulmonary arterial hypertension : Adaptive versus maladaptive morphology. / Badagliacca, Roberto; Poscia, Roberto; Pezzuto, Beatrice; Nocioni, Martina; Mezzapesa, Mario; Francone, Marco; Giannetta, Elisa; Papa, Silvia; Gambardella, Cristina; Sciomer, Susanna; Volterrani, Maurizio; Fedele, Francesco; Dario Vizza, Carmine.

In: Journal of Heart and Lung Transplantation, Vol. 34, No. 3, 01.03.2015, p. 395-403.

Research output: Contribution to journalArticle

Badagliacca, R, Poscia, R, Pezzuto, B, Nocioni, M, Mezzapesa, M, Francone, M, Giannetta, E, Papa, S, Gambardella, C, Sciomer, S, Volterrani, M, Fedele, F & Dario Vizza, C 2015, 'Right ventricular remodeling in idiopathic pulmonary arterial hypertension: Adaptive versus maladaptive morphology', Journal of Heart and Lung Transplantation, vol. 34, no. 3, pp. 395-403. https://doi.org/10.1016/j.healun.2014.11.002
Badagliacca, Roberto ; Poscia, Roberto ; Pezzuto, Beatrice ; Nocioni, Martina ; Mezzapesa, Mario ; Francone, Marco ; Giannetta, Elisa ; Papa, Silvia ; Gambardella, Cristina ; Sciomer, Susanna ; Volterrani, Maurizio ; Fedele, Francesco ; Dario Vizza, Carmine. / Right ventricular remodeling in idiopathic pulmonary arterial hypertension : Adaptive versus maladaptive morphology. In: Journal of Heart and Lung Transplantation. 2015 ; Vol. 34, No. 3. pp. 395-403.
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T2 - Adaptive versus maladaptive morphology

AU - Badagliacca, Roberto

AU - Poscia, Roberto

AU - Pezzuto, Beatrice

AU - Nocioni, Martina

AU - Mezzapesa, Mario

AU - Francone, Marco

AU - Giannetta, Elisa

AU - Papa, Silvia

AU - Gambardella, Cristina

AU - Sciomer, Susanna

AU - Volterrani, Maurizio

AU - Fedele, Francesco

AU - Dario Vizza, Carmine

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N2 - Background Although increased pulmonary pressure is caused by changes in the pulmonary vasculature, prognosis in idiopathic pulmonary arterial hypertension (IPAH) is strongly associated with right ventricular (RV) function. The aim of this study was to describe the best RV adaptive remodeling pattern to increased afterload in IPAH. Methods In 60 consecutive patients with IPAH, RV morphologic and functional features were evaluated by echocardiography and cardiac magnetic resonance imaging. To address the question of the best RV adaptation pattern, we divided the study population into two groups by the median value of RV mass/volume ratio (0.46) because this parameter allows the distinction between RV eccentric (≤0.46) and concentric hypertrophy (>0.46). The two groups were compared for RV remodeling and systolic function parameters, World Health Organization class, pulmonary hemodynamics, and 6-minute walk test. Results Despite similar pulmonary vascular resistance, mean pulmonary pressure, and compliance, patients with eccentric hypertrophy had advanced World Health Organization class and worse 6-minute walk test, hemodynamics, RV remodeling, and systolic function parameters compared with patients with concentric hypertrophy. The group with concentric hypertrophy had higher RV to pulmonary arterial coupling compared with the group with eccentric hypertrophy (1.24 ± 0.26 vs 0.83 ± 0.33, p = 0.0001), indicating higher RV efficiency. A significant correlation was found between pulmonary vascular resistance and RV to pulmonary arterial coupling (r = -0.55, = 0.31, p = 0.0001), with patients with RV mass/volume ratio > 0.46 at the higher part of the scatterplot, confirming more adequate RV function. Conclusions Concentric hypertrophy might represent a more favorable RV adaptive remodeling pattern to increased afterload in IPAH because it is associated with more suitable systolic function and mechanical efficiency.

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KW - echocardiography

KW - pulmonary arterial hypertension

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