Right ventricular total isovolumic time: Reference value study

Guido Tavazzi, Andrea Boffi, Gabriele Savioli, Alessandra Greco, Claudia Pavesi, Catherine Klersy, Stefania Guida, Giorgio Iotti, Francesco Mojoli, Stefano Ghio, Gabriele Via, Paolo Barbier, Claudia Raineri, Gaetano Maria De Ferrari, Susanna Price

Research output: Contribution to journalArticlepeer-review


Background: There is lack of noninvasive indices to detail the right side cardiovascular physiology. Total isovolumic time (tIVT) is a sensitive marker of left ventricular electromechanical efficiency and systolic-diastolic interaction. The aim of the study was to evaluate normal reference value of the right ventricular tIVT with increasing age. Methods and results: One hundred and eighty-one healthy volunteers (51% male) underwent transthoracic echocardiography. The population was divided into four categories according to age: A < 30 years; B 30–39 years; C 40–49 years; and C ≥ 50 years old. tIVT was computed in seconds/minutes as: 60 – (tET + tFT). tET and tFT are the total ejection and filling time adjusted by the heart rate, measured, respectively, from the onset to the end of the right ventricle (RV) forward flow through the pulmonary valve and from the onset of the E-wave and the end of the A-wave at the level of the tricuspid valve. The mean RV tIVT was 7 ± 1.1 s/min and increased significantly with age, from a 3.4 to 9.7 s/min(P < 0.0001). Significant correlation was found between tIVT and trans-tricuspid E/E′ (P < 0.0001; 0.78 (95% CI: 0.715–0.831) while weaker between tIVT and E/A (P = 0.001; −0.283 95% CI: −0.413 to −0.143). Conclusion: The normal values of RV tIVT increase with age and correlate significantly with Doppler diastolic parameters.

Original languageEnglish
Publication statusPublished - Jan 1 2019


  • diastolic function
  • echocardiography
  • reference values
  • right ventricle
  • total isovolumic time

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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