Rise and fall of HCV-related hepatocellular carcinoma in Italy: A long-term survey from the ITA.LI.CA centres

Nora Cazzagon, Franco Trevisani, Gemma Maddalo, Anna Giacomin, Veronica Vanin, Caterina Pozzan, Paolo Del Poggio, Gianludovico Rapaccini, Anna M Di Nolfo, Luisa Benvegnù, Marco Zoli, Franco Borzio, Edoardo G. Giannini, Eugenio Caturelli, Maria Chiaramonte, Francesco G. Foschi, Giuseppe Cabibbo, Martina Felder, Francesca Ciccarese, Gabriele MissaleGianluca Svegliati Baroni, Filomena Morisco, Anna Pecorelli, Fabio Farinati

Research output: Contribution to journalArticlepeer-review


Background & Aims: Hepatitis C virus (HCV) is the leading aetiological factor of HCC in the western world where, overall, its incidence is increasing, despite data suggesting an initial drop in some areas. The aim of this study was to evaluate epidemiology, clinical features and survival of HCV-related HCC (HCV-HCC) in a wide time range in Italy. Methods: Multicentre retrospective study including 3695 patients prospectively recruited by the ITA.LI.CA group. Patients were classified into three subgroups according to aetiology (Group A[GA], pure HCV; Group B[GB], HCV + cofactors; and Group C[GC], non-HCV) and in 5 time cohorts (5 years each), according to the year of diagnosis. Age, gender, Child-Pugh score, modality of diagnosis, stage, presence of thrombosis/metastases, type of treatment and survival were analysed. Results: A total of 1801 GA patients, 445 GB and 1333 GC were recruited. The number of GA patients peaked in the 1996-2000, gradually dropping thereafter (P <0.0001), as observed for GB (P <0.0001). Age at diagnosis increased (P <0.0001), while percentage of patients diagnosed during surveillance and stage improved only in GA (P = 0.02 and P = 0.003 respectively). The survival significantly increased over time particularly in GA (median 37 months) and was longer in GA than in GB and GC (P <0.0001). Conclusions: The prevalence of HCC-HCV is decreasing in Italy since 2001. HCV-HCC patients are older, more frequently diagnosed under surveillance and in an earlier stage. HCC survival improved in the last 15 years and is significantly higher in patients with HCV-HCC. We therefore expect a further drop in both incidence and mortality for HCV-HCC in the years to come.

Original languageEnglish
Pages (from-to)1420-1427
Number of pages8
JournalLiver International
Issue number9
Publication statusPublished - Oct 2013


  • Cirrhosis
  • Hepatitis C
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Hepatology


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