Rise of TRIM8: A Molecule of Duality

Research output: Contribution to journalReview articlepeer-review

Abstract

The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endorse this dual character of TRIM8, we appraise the game-changing capacity of TRIM8 under stress conditions against the backdrop of cell proliferation, apoptosis, and cancer, and also highlight the duality of TRIM8 in multiple contexts like cellular localization, stress-induced conditions, and E3 ubiquitin ligase activity. Finally, we discuss the emerging role of TRIM8 during bipolar spindle formation and mitotic progression, and its growing sphere of influence across multiple human cancers and pathologies, and suggest TRIM8-linked axes that can be modulated further for anti-cancer therapeutics development.

Original languageEnglish
Pages (from-to)434-444
Number of pages11
JournalMolecular Therapy - Nucleic Acids
Volume22
DOIs
Publication statusPublished - Dec 4 2020

Keywords

  • cancer
  • E3 ubiquitin ligases
  • TRIM family
  • TRIM8

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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