Rising levels of human cytomegalovirus (HCMV) antigenemia during initial antiviral treatment of solid-organ transplant recipients with primary HCMV infection

G. Gerna, M. Zavattoni, E. Percivalle, P. Grossi, M. Torsellini, M. G. Revello

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

In 7 of 18 solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, HCMV antigenemia levels were unexpectedly found to rise significantly (P = 0.018) during a mean time of 7.3 ± 3.2 days after initiation of specific antiviral treatment, whereas corresponding levels of viremia dropped significantly (P = 0.043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients.

Original languageEnglish
Pages (from-to)1113-1116
Number of pages4
JournalJournal of Clinical Microbiology
Volume36
Issue number4
Publication statusPublished - 1998

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Cytomegalovirus Infections
Cytomegalovirus
Antiviral Agents
Transplants
Viremia
Therapeutics
Transplant Recipients

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

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abstract = "In 7 of 18 solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, HCMV antigenemia levels were unexpectedly found to rise significantly (P = 0.018) during a mean time of 7.3 ± 3.2 days after initiation of specific antiviral treatment, whereas corresponding levels of viremia dropped significantly (P = 0.043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients.",
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AU - Gerna, G.

AU - Zavattoni, M.

AU - Percivalle, E.

AU - Grossi, P.

AU - Torsellini, M.

AU - Revello, M. G.

PY - 1998

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AB - In 7 of 18 solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, HCMV antigenemia levels were unexpectedly found to rise significantly (P = 0.018) during a mean time of 7.3 ± 3.2 days after initiation of specific antiviral treatment, whereas corresponding levels of viremia dropped significantly (P = 0.043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients.

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