Risk and determinants of dementia in patients with mild cognitive impairment and brain subcortical vascular changes: A study of clinical, neuroimaging, and biological MarkersThe VMCI-Tuscany Study: Rationale, design, and methodology

Anna Poggesi, Emilia Salvadori, Leonardo Pantoni, Giovanni Pracucci, Francesca Cesari, Alberto Chiti, Laura Ciolli, Mirco Cosottini, Alessandra Del Bene, Nicola De Stefano, Stefano Diciotti, Maria Teresa Dotti, Andrea Ginestroni, Betti Giusti, Anna Maria Gori, Serena Nannucci, Giovanni Orlandi, Francesca Pescini, Raffaella Valenti, Rosanna AbbateAntonio Federico, Mario Mascalchi, Luigi Murri, Domenico Inzitari

Research output: Contribution to journalArticle

Abstract

Dementia is one of the most disabling conditions. Alzheimers disease and vascular dementia (VaD) are the most frequent causes. Subcortical VaD is consequent to deep-brain small vessel disease (SVD) and is the most frequent form of VaD. Its pathological hallmarks are ischemic white matter changes and lacunar infarcts. Degenerative and vascular changes often coexist, but mechanisms of interaction are incompletely understood. The term mild cognitive impairment defines a transitional state between normal ageing and dementia. Pre-dementia stages of VaD are also acknowledged (vascular mild cognitive impairment, VMCI). Progression relates mostly to the subcortical VaD type, but determinants of such transition are unknown. Variability of phenotypic expression is not fully explained by severity grade of lesions, as depicted by conventional MRI that is not sensitive to microstructural and metabolic alterations. Advanced neuroimaging techniques seem able to achieve this. Beside hypoperfusion, blood-brain-barrier dysfunction has been also demonstrated in subcortical VaD. The aim of the Vascular Mild Cognitive Impairment Tuscany Study is to expand knowledge about determinants of transition from mild cognitive impairment to dementia in patients with cerebral SVD. This paper summarizes the main aims and methodological aspects of this multicenter, ongoing, observational study enrolling patients affected by VMCI with SVD.

Original languageEnglish
Article number608013
JournalInternational Journal of Alzheimer's Disease
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Ageing
  • Cellular and Molecular Neuroscience
  • Neurology

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    Poggesi, A., Salvadori, E., Pantoni, L., Pracucci, G., Cesari, F., Chiti, A., Ciolli, L., Cosottini, M., Del Bene, A., De Stefano, N., Diciotti, S., Dotti, M. T., Ginestroni, A., Giusti, B., Gori, A. M., Nannucci, S., Orlandi, G., Pescini, F., Valenti, R., ... Inzitari, D. (2012). Risk and determinants of dementia in patients with mild cognitive impairment and brain subcortical vascular changes: A study of clinical, neuroimaging, and biological MarkersThe VMCI-Tuscany Study: Rationale, design, and methodology. International Journal of Alzheimer's Disease, [608013]. https://doi.org/10.1155/2012/608013