La valutazione del rischio nel personale ospedaliero addetto alla preparazione e alla somministrazione di farmaci antitumorali.

Translated title of the contribution: Risk assessment concerning hospital personnel participating in the preparation and administration of antineoplastic drugs

C. Minoia, R. Turci, C. Sottani, A. Schiavi, L. Perbellini, S. Angeleri, F. Frigerio, F. Draicchio, P. Apostoli

Research output: Contribution to journalArticle

Abstract

24 workers (10 involved in the preparation and 14 in administration) exposed to cyclophosphamide (CP) and ifosfamide (IF) in two Italian hospitals were monitored. The extent of exposure was assessed by the analysis of air samples, wipe samples, pads and gloves. Urinary excretion at the beginning and at the end of the work shift was also measured by liquid-liquid extraction and analysis by HPLC-MS/MS. 3 out of 24 air samples resulted to be positive for CP or IF. In wipe samples, CP concentrations ranging from <0.001 to 82.4 micrograms/dm2 in Hospital A (32 samples) and from 0.2 to 383.3 micrograms/dm2 in Hospital B (17 samples), were found. IF concentrations varied from <0.001 to 90.9 micrograms/dm2 in Hospital A and from 0.01 to 141.5 micrograms/dm2 in Hospital B. Pads (from 11 to 13 for each operator) were contaminated with CP and IF especially on arms, legs and chest. The use of a plastic-backed liner on the working tray in the laminar flow hoods was demonstrated to compromise the containment properties of the hood. Urine samples were positive for CP in 50% of the workers (range: 0.1-2.1 micrograms/L), whereas IF was detected in 2 subjects only (range: 0.1-0.8 microgram/L). The results from this investigation demonstrated that vertical laminar airflow hoods, when incorrectly used, might represent a source of contamination and that higher risk may depend on lack of educational programmes and observance of preventive guidelines.

Translated title of the contributionRisk assessment concerning hospital personnel participating in the preparation and administration of antineoplastic drugs
Original languageItalian
Pages (from-to)93-107
Number of pages15
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume21
Issue number2
Publication statusPublished - 1999

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