Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae

Roberta Prinapori; Julie Guinaud; Antoine Khalil; Herve Lecuyer; Dominique Gendrel; Olivier Lortholary; Xavier Nassif; Claudio Viscoli; Jean Ralph Zahar

doi:10.1016/j.ajic.2012.03.035

Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae

Roberta Prinapori, Julie Guinaud, Antoine Khalil, Herve Lecuyer, Dominique Gendrel, Olivier Lortholary, Xavier Nassif, Claudio Viscoli, Jean Ralph Zahar

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated 74 children with previous fecal extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae colonization who were hospitalized and receiving a course of antibiotic therapy for suspected infection. Sixty-four patients (86.5%) received a carbapenem agent. Only 3 patients were infected with an ESBL-producing Enterobacteriaceae. Sixty-one (95%) initial antibiotic courses were considered excessive and required deescalation; however, deescalation was accomplished in only 38 patients (62%). This suggests the need for an ESBL control program to decrease carbapenem use and thereby limit carbapenem resistance in gram-negative bacilli.

Original language	English
Pages (from-to)	259-260
Number of pages	2
Journal	AJIC: American Journal of Infection Control
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/j.ajic.2012.03.035
Publication status	Published - Mar 2013

Keywords

Bloodstream infection
Carbapenems
Deescalation

ASJC Scopus subject areas

Infectious Diseases
Public Health, Environmental and Occupational Health
Epidemiology
Health Policy

Access to Document

10.1016/j.ajic.2012.03.035

Cite this

Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae. / Prinapori, Roberta; Guinaud, Julie; Khalil, Antoine; Lecuyer, Herve; Gendrel, Dominique; Lortholary, Olivier; Nassif, Xavier; Viscoli, Claudio; Zahar, Jean Ralph.

In: AJIC: American Journal of Infection Control, Vol. 41, No. 3, 03.2013, p. 259-260.

Research output: Contribution to journal › Article › peer-review

@article{187a265a4abf4db0b52bc63b37485eb6,

title = "Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae",

abstract = "We evaluated 74 children with previous fecal extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae colonization who were hospitalized and receiving a course of antibiotic therapy for suspected infection. Sixty-four patients (86.5%) received a carbapenem agent. Only 3 patients were infected with an ESBL-producing Enterobacteriaceae. Sixty-one (95%) initial antibiotic courses were considered excessive and required deescalation; however, deescalation was accomplished in only 38 patients (62%). This suggests the need for an ESBL control program to decrease carbapenem use and thereby limit carbapenem resistance in gram-negative bacilli.",

keywords = "Bloodstream infection, Carbapenems, Deescalation",

author = "Roberta Prinapori and Julie Guinaud and Antoine Khalil and Herve Lecuyer and Dominique Gendrel and Olivier Lortholary and Xavier Nassif and Claudio Viscoli and Zahar, {Jean Ralph}",

year = "2013",

month = mar,

doi = "10.1016/j.ajic.2012.03.035",

language = "English",

volume = "41",

pages = "259--260",

journal = "American Journal of Infection Control",

issn = "0196-6553",

publisher = "Mosby Inc.",

number = "3",

}

TY - JOUR

T1 - Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae

AU - Prinapori, Roberta

AU - Guinaud, Julie

AU - Khalil, Antoine

AU - Lecuyer, Herve

AU - Gendrel, Dominique

AU - Lortholary, Olivier

AU - Nassif, Xavier

AU - Viscoli, Claudio

AU - Zahar, Jean Ralph

PY - 2013/3

Y1 - 2013/3

N2 - We evaluated 74 children with previous fecal extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae colonization who were hospitalized and receiving a course of antibiotic therapy for suspected infection. Sixty-four patients (86.5%) received a carbapenem agent. Only 3 patients were infected with an ESBL-producing Enterobacteriaceae. Sixty-one (95%) initial antibiotic courses were considered excessive and required deescalation; however, deescalation was accomplished in only 38 patients (62%). This suggests the need for an ESBL control program to decrease carbapenem use and thereby limit carbapenem resistance in gram-negative bacilli.

AB - We evaluated 74 children with previous fecal extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae colonization who were hospitalized and receiving a course of antibiotic therapy for suspected infection. Sixty-four patients (86.5%) received a carbapenem agent. Only 3 patients were infected with an ESBL-producing Enterobacteriaceae. Sixty-one (95%) initial antibiotic courses were considered excessive and required deescalation; however, deescalation was accomplished in only 38 patients (62%). This suggests the need for an ESBL control program to decrease carbapenem use and thereby limit carbapenem resistance in gram-negative bacilli.

KW - Bloodstream infection

KW - Carbapenems

KW - Deescalation

UR - http://www.scopus.com/inward/record.url?scp=84875364040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875364040&partnerID=8YFLogxK

U2 - 10.1016/j.ajic.2012.03.035

DO - 10.1016/j.ajic.2012.03.035

M3 - Article

C2 - 23062579

AN - SCOPUS:84875364040

VL - 41

SP - 259

EP - 260

JO - American Journal of Infection Control

JF - American Journal of Infection Control

SN - 0196-6553

IS - 3

ER -

Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this