Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae

Roberta Prinapori; Julie Guinaud; Antoine Khalil; Herve Lecuyer; Dominique Gendrel; Olivier Lortholary; Xavier Nassif; Claudio Viscoli; Jean Ralph Zahar

doi:10.1016/j.ajic.2012.03.035

Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae

Roberta Prinapori, Julie Guinaud, Antoine Khalil, Herve Lecuyer, Dominique Gendrel, Olivier Lortholary, Xavier Nassif, Claudio Viscoli, Jean Ralph Zahar

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated 74 children with previous fecal extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae colonization who were hospitalized and receiving a course of antibiotic therapy for suspected infection. Sixty-four patients (86.5%) received a carbapenem agent. Only 3 patients were infected with an ESBL-producing Enterobacteriaceae. Sixty-one (95%) initial antibiotic courses were considered excessive and required deescalation; however, deescalation was accomplished in only 38 patients (62%). This suggests the need for an ESBL control program to decrease carbapenem use and thereby limit carbapenem resistance in gram-negative bacilli.

Original language	English
Pages (from-to)	259-260
Number of pages	2
Journal	AJIC: American Journal of Infection Control
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/j.ajic.2012.03.035
Publication status	Published - Mar 2013

Keywords

Bloodstream infection
Carbapenems
Deescalation

ASJC Scopus subject areas

Infectious Diseases
Public Health, Environmental and Occupational Health
Epidemiology
Health Policy

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Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae. / Prinapori, Roberta; Guinaud, Julie; Khalil, Antoine; Lecuyer, Herve; Gendrel, Dominique; Lortholary, Olivier; Nassif, Xavier; Viscoli, Claudio; Zahar, Jean Ralph.

In: AJIC: American Journal of Infection Control, Vol. 41, No. 3, 03.2013, p. 259-260.

Research output: Contribution to journal › Article › peer-review

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