TY - JOUR
T1 - Risk attitude and personality in people with multiple sclerosis facing the choice of different disease-modifying therapy scenarios
AU - Minacapelli, Eleonora
AU - Giordano, Andrea
AU - Falautano, Monica
AU - Sangalli, Francesca
AU - Pietrolongo, Erika
AU - Lorefice, Lorena
AU - Cocco, Eleonora
AU - Lugaresi, Alessandra
AU - Filippi, Massimo
AU - Comi, Giancarlo
AU - Martinelli, Vittorio
N1 - Ricercatore distaccato presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Lugaresi Alessandra)
PY - 2020/10/15
Y1 - 2020/10/15
N2 - Background: As available disease-modifying therapies (DMTs) increase, evaluating benefit/risk presents greater difficulties, requiring people with MS (PwMS) to play crucial roles in choosing treatment. Although individual attitude toward risk may predict this evaluation, its relation to personality is little studied in MS literature. Objective: To prospectively assess risk attitudes and personality traits of PwMS choosing a DMT. Methods: In three Italian MS centers (2012–2015), 420 PwMS completed an ad hoc questionnaire on socio-demographic variables, personality, and standard-gamble questions, to evaluate MS- and DMT-related risks through two hypothetical drug scenarios. We assessed the influence of previously collected socio-demographic/clinical characteristics, and personality factors on risk attitude. Results: Almost half of participants were mainly concerned about progressive multifocal leukoencephalopathy; <25% about relapses. Median acceptable risk of death for both hypothetical drug scenarios was 1:10,000; 19–20% would not take any risk related to DMT. Regression analysis revealed that being male, more educated, and with higher impulsivity/sensation-seeking propensity was significantly associated with a higher risk attitude. Conclusions: Both socio-demographic and personality factors affect risk attitude of PwMS facing different DMT scenarios. These findings could affect the shared decision-making process in selecting best treatment option for PwMS.
AB - Background: As available disease-modifying therapies (DMTs) increase, evaluating benefit/risk presents greater difficulties, requiring people with MS (PwMS) to play crucial roles in choosing treatment. Although individual attitude toward risk may predict this evaluation, its relation to personality is little studied in MS literature. Objective: To prospectively assess risk attitudes and personality traits of PwMS choosing a DMT. Methods: In three Italian MS centers (2012–2015), 420 PwMS completed an ad hoc questionnaire on socio-demographic variables, personality, and standard-gamble questions, to evaluate MS- and DMT-related risks through two hypothetical drug scenarios. We assessed the influence of previously collected socio-demographic/clinical characteristics, and personality factors on risk attitude. Results: Almost half of participants were mainly concerned about progressive multifocal leukoencephalopathy; <25% about relapses. Median acceptable risk of death for both hypothetical drug scenarios was 1:10,000; 19–20% would not take any risk related to DMT. Regression analysis revealed that being male, more educated, and with higher impulsivity/sensation-seeking propensity was significantly associated with a higher risk attitude. Conclusions: Both socio-demographic and personality factors affect risk attitude of PwMS facing different DMT scenarios. These findings could affect the shared decision-making process in selecting best treatment option for PwMS.
KW - Decision-making
KW - Disease-modifying therapies
KW - Multiple sclerosis
KW - Personality
KW - Risk attitude
KW - Shared decision-making
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U2 - 10.1016/j.jns.2020.117064
DO - 10.1016/j.jns.2020.117064
M3 - Article
C2 - 32763510
AN - SCOPUS:85088970206
VL - 417
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
M1 - 117064
ER -