Fattori di rischio e prevenzione del carcinoma della tiroide.

Translated title of the contribution: Risk factors and prevention of thyroid carcinoma

G. Lupoli, E. Cascone, G. Vitale, F. Arlotta, V. Nuzzo, G. Lupoli, B. Cassese

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Thyroid carcinoma represents the most frequent endocrine tumor. Recent reports have documented an increase in the incidence of thyroid cancer. Its incidence varies geographically around the world from 0.9/ 100,000 men and 2.4/100,000 women in Great Britain to 8.8/100,000 men and 18.2/ 100,000 women in Hawaii. Radiation exposure has been strongly implicated as an aetiological factor. The greatest risk occurs with acute exposure to X and/or gamma rays, with a linear dose response curve, while the risk is inversely related to age at exposure with a latent period of 5-20 years. Together with irradiation, other factors (iodine, alcohol and calcium diet intake, hyperthyroidism, Hashi-moto's thyroiditis, Gardner syndrome, Cowden syndrome, pharmaceutical agents, hormonal factors, occupational exposure, activation of cellular oncogenes) have been associated with the risk of thyroid cancer. In prevention a policy should include regulations and methods for avoiding radiation exposure of the thyroid and for preventing nutritional deficiency and excess of iodine. Besides, early and continuous suppressive therapy of all patients affected by non-toxic goiter or treated previously with thyroidectomy, and a screening of medullary thyroid carcinoma (MTC) using pentagastrin stimulation test and restriction fragment length polymorphism analysis, in subjects with a familial history of MTC, are of paramount importance to prevent thyroid cancer.

Original languageItalian
Pages (from-to)93-100
Number of pages8
JournalMinerva Endocrinologica
Volume21
Issue number3
Publication statusPublished - Sep 1996

Fingerprint

Thyroid Neoplasms
Iodine
Gardner Syndrome
Multiple Hamartoma Syndrome
Thyroiditis
Pentagastrin
Gamma Rays
Incidence
Thyroidectomy
Goiter
Hyperthyroidism
Occupational Exposure
Oncogenes
Malnutrition
Restriction Fragment Length Polymorphisms
Thyroid Gland
Alcohols
X-Rays
Diet
Calcium

Cite this

Lupoli, G., Cascone, E., Vitale, G., Arlotta, F., Nuzzo, V., Lupoli, G., & Cassese, B. (1996). Fattori di rischio e prevenzione del carcinoma della tiroide. Minerva Endocrinologica, 21(3), 93-100.

Fattori di rischio e prevenzione del carcinoma della tiroide. / Lupoli, G.; Cascone, E.; Vitale, G.; Arlotta, F.; Nuzzo, V.; Lupoli, G.; Cassese, B.

In: Minerva Endocrinologica, Vol. 21, No. 3, 09.1996, p. 93-100.

Research output: Contribution to journalArticle

Lupoli, G, Cascone, E, Vitale, G, Arlotta, F, Nuzzo, V, Lupoli, G & Cassese, B 1996, 'Fattori di rischio e prevenzione del carcinoma della tiroide.', Minerva Endocrinologica, vol. 21, no. 3, pp. 93-100.
Lupoli G, Cascone E, Vitale G, Arlotta F, Nuzzo V, Lupoli G et al. Fattori di rischio e prevenzione del carcinoma della tiroide. Minerva Endocrinologica. 1996 Sep;21(3):93-100.
Lupoli, G. ; Cascone, E. ; Vitale, G. ; Arlotta, F. ; Nuzzo, V. ; Lupoli, G. ; Cassese, B. / Fattori di rischio e prevenzione del carcinoma della tiroide. In: Minerva Endocrinologica. 1996 ; Vol. 21, No. 3. pp. 93-100.
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