Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis

Antonella Tufano, Anna Guida, Antonio Coppola, Assunta Nardo, Mirko Di Capua, Gabriele Quintavalle, Matteo Nicola Dario Di Minno, Anna Maria Cerbone, Giovanni Di Minno

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background. The prevalence of thrombophilic abnormalities in patients with cerebral vein thrombosis has been reported to be similar to that in patients with deep vein thrombosis of the lower limb. The role of gender-specific risk factors (pregnancy, oral contraceptives) is well established, whereas that of other acquired risk conditions is debated. Materials and methods. We screened 56 patients with cerebral vein thrombosis and 184 age- and sex-matched apparently healthy controls for prothrombin (factor II, FII) G20210A and factor V Leiden polymorphisms; protein S, protein C, and antithrombin deficiency; anticardiolipin antibodies; hyperhomocysteinaemia and other putative risk factors. Results. The G20210A polymorphism was found in 29.1% of patients and in 5.7% of controls (odds ratio [OR] 7.1; P

Original languageEnglish
JournalBlood Transfusion
Volume12
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2014

Fingerprint

Intracranial Thrombosis
Venous Thrombosis
Cerebral Veins
Prothrombin
Protein C Deficiency
Anticardiolipin Antibodies
Hyperhomocysteinemia
Antithrombins
Protein S
Oral Contraceptives
Lower Extremity
Odds Ratio
Pregnancy

Keywords

  • Cerebral venous thrombosis
  • Recurrences
  • Risk factors

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

Cite this

Tufano, A., Guida, A., Coppola, A., Nardo, A., Capua, M. D., Quintavalle, G., ... Di Minno, G. (2014). Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis. Blood Transfusion, 12(SUPPL.1). https://doi.org/10.2450/2013.0196-12

Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis. / Tufano, Antonella; Guida, Anna; Coppola, Antonio; Nardo, Assunta; Capua, Mirko Di; Quintavalle, Gabriele; Di Minno, Matteo Nicola Dario; Cerbone, Anna Maria; Di Minno, Giovanni.

In: Blood Transfusion, Vol. 12, No. SUPPL.1, 2014.

Research output: Contribution to journalArticle

Tufano, A, Guida, A, Coppola, A, Nardo, A, Capua, MD, Quintavalle, G, Di Minno, MND, Cerbone, AM & Di Minno, G 2014, 'Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis', Blood Transfusion, vol. 12, no. SUPPL.1. https://doi.org/10.2450/2013.0196-12
Tufano, Antonella ; Guida, Anna ; Coppola, Antonio ; Nardo, Assunta ; Capua, Mirko Di ; Quintavalle, Gabriele ; Di Minno, Matteo Nicola Dario ; Cerbone, Anna Maria ; Di Minno, Giovanni. / Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis. In: Blood Transfusion. 2014 ; Vol. 12, No. SUPPL.1.
@article{92c5ae742bdc455081608dda818afcfd,
title = "Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis",
abstract = "Background. The prevalence of thrombophilic abnormalities in patients with cerebral vein thrombosis has been reported to be similar to that in patients with deep vein thrombosis of the lower limb. The role of gender-specific risk factors (pregnancy, oral contraceptives) is well established, whereas that of other acquired risk conditions is debated. Materials and methods. We screened 56 patients with cerebral vein thrombosis and 184 age- and sex-matched apparently healthy controls for prothrombin (factor II, FII) G20210A and factor V Leiden polymorphisms; protein S, protein C, and antithrombin deficiency; anticardiolipin antibodies; hyperhomocysteinaemia and other putative risk factors. Results. The G20210A polymorphism was found in 29.1{\%} of patients and in 5.7{\%} of controls (odds ratio [OR] 7.1; P",
keywords = "Cerebral venous thrombosis, Recurrences, Risk factors",
author = "Antonella Tufano and Anna Guida and Antonio Coppola and Assunta Nardo and Capua, {Mirko Di} and Gabriele Quintavalle and {Di Minno}, {Matteo Nicola Dario} and Cerbone, {Anna Maria} and {Di Minno}, Giovanni",
year = "2014",
doi = "10.2450/2013.0196-12",
language = "English",
volume = "12",
journal = "Blood Transfusion",
issn = "1723-2007",
publisher = "Edizioni SIMTI",
number = "SUPPL.1",

}

TY - JOUR

T1 - Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis

AU - Tufano, Antonella

AU - Guida, Anna

AU - Coppola, Antonio

AU - Nardo, Assunta

AU - Capua, Mirko Di

AU - Quintavalle, Gabriele

AU - Di Minno, Matteo Nicola Dario

AU - Cerbone, Anna Maria

AU - Di Minno, Giovanni

PY - 2014

Y1 - 2014

N2 - Background. The prevalence of thrombophilic abnormalities in patients with cerebral vein thrombosis has been reported to be similar to that in patients with deep vein thrombosis of the lower limb. The role of gender-specific risk factors (pregnancy, oral contraceptives) is well established, whereas that of other acquired risk conditions is debated. Materials and methods. We screened 56 patients with cerebral vein thrombosis and 184 age- and sex-matched apparently healthy controls for prothrombin (factor II, FII) G20210A and factor V Leiden polymorphisms; protein S, protein C, and antithrombin deficiency; anticardiolipin antibodies; hyperhomocysteinaemia and other putative risk factors. Results. The G20210A polymorphism was found in 29.1% of patients and in 5.7% of controls (odds ratio [OR] 7.1; P

AB - Background. The prevalence of thrombophilic abnormalities in patients with cerebral vein thrombosis has been reported to be similar to that in patients with deep vein thrombosis of the lower limb. The role of gender-specific risk factors (pregnancy, oral contraceptives) is well established, whereas that of other acquired risk conditions is debated. Materials and methods. We screened 56 patients with cerebral vein thrombosis and 184 age- and sex-matched apparently healthy controls for prothrombin (factor II, FII) G20210A and factor V Leiden polymorphisms; protein S, protein C, and antithrombin deficiency; anticardiolipin antibodies; hyperhomocysteinaemia and other putative risk factors. Results. The G20210A polymorphism was found in 29.1% of patients and in 5.7% of controls (odds ratio [OR] 7.1; P

KW - Cerebral venous thrombosis

KW - Recurrences

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84893922669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893922669&partnerID=8YFLogxK

U2 - 10.2450/2013.0196-12

DO - 10.2450/2013.0196-12

M3 - Article

C2 - 23399370

AN - SCOPUS:84893922669

VL - 12

JO - Blood Transfusion

JF - Blood Transfusion

SN - 1723-2007

IS - SUPPL.1

ER -