Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis

Antonella Tufano, Anna Guida, Antonio Coppola, Assunta Nardo, Mirko Di Capua, Gabriele Quintavalle, Matteo Nicola Dario Di Minno, Anna Maria Cerbone, Giovanni Di Minno

Research output: Contribution to journalArticlepeer-review

Abstract

Background. The prevalence of thrombophilic abnormalities in patients with cerebral vein thrombosis has been reported to be similar to that in patients with deep vein thrombosis of the lower limb. The role of gender-specific risk factors (pregnancy, oral contraceptives) is well established, whereas that of other acquired risk conditions is debated. Materials and methods. We screened 56 patients with cerebral vein thrombosis and 184 age- and sex-matched apparently healthy controls for prothrombin (factor II, FII) G20210A and factor V Leiden polymorphisms; protein S, protein C, and antithrombin deficiency; anticardiolipin antibodies; hyperhomocysteinaemia and other putative risk factors. Results. The G20210A polymorphism was found in 29.1% of patients and in 5.7% of controls (odds ratio [OR] 7.1; P

Original languageEnglish
JournalBlood Transfusion
Volume12
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2014

Keywords

  • Cerebral venous thrombosis
  • Recurrences
  • Risk factors

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

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