Risk factors and surgical management of anastomotic biliary complications after pediatric liver transplantation

Tom Darius, Jairo Rivera, Fabio Fusaro, Quirino Lai, Catherine De Magnée, Christophe Bourdeaux, Magdalena Janssen, Philippe Clapuyt, Raymond Reding

Research output: Contribution to journalArticle

Abstract

Biliary complications (BCs) still remain the Achilles heel of liver transplantation (LT) with an overall incidence of 10% to 35% in pediatric series. We hypothesized that (1) the use of alternative techniques (reduced size, split, and living donor grafts) in pediatric LT may contribute to an increased incidence of BCs, and (2) surgery as a first treatment option for anastomotic BCs could allow a definitive cure for the majority of these patients. Four hundred twenty-nine primary pediatric LT procedures, including 88, 91, 47, and 203 whole, reduced size, split, and living donor grafts, respectively, that were performed between July 1993 and November 2010 were retrospectively reviewed. Demographic and surgical variables were analyzed, and their respective impact on BCs was studied with univariate and multivariate analyses. The modalities of BC management were also reviewed. The 1- and 5-year patient survival rates were 94% and 90%, 89% and 85%, 94% and 89%, and 98% and 94% for whole, reduced size, split, and living donor liver grafts, respectively. The overall incidence of BCs was 23% (n = 98). Sixty were anastomotic complications [47 strictures (78%) and 13 fistulas (22%)]. The graft type was not found to be an independent risk factor for the development of BCs. According to a multivariate analysis, only hepatic artery thrombosis and acute rejection increased the risk of anastomotic BCs (P <0.001 and P = 0.003, respectively). Anastomotic BCs were managed primarily with surgical repair in 59 of 60 cases with a primary patency rate of 80% (n = 47). These results suggest that (1) most of the BCs were anastomotic complications not influenced by the type of graft, and (2) the surgical management of anastomotic BCs may constitute the first and best therapeutic option.

Original languageEnglish
Pages (from-to)893-903
Number of pages11
JournalLiver Transplantation
Volume20
Issue number8
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Hepatology
  • Medicine(all)

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    Darius, T., Rivera, J., Fusaro, F., Lai, Q., De Magnée, C., Bourdeaux, C., Janssen, M., Clapuyt, P., & Reding, R. (2014). Risk factors and surgical management of anastomotic biliary complications after pediatric liver transplantation. Liver Transplantation, 20(8), 893-903. https://doi.org/10.1002/lt.23910