TY - JOUR
T1 - Risk factors associated with complications/sequelae of acute and subacute haematogenous osteomyelitis
T2 - an Italian multicenter study
AU - Chiappini, Elena
AU - Krzysztofiak, Andrzej
AU - Bozzola, Elena
AU - Gabiano, Clara
AU - Esposito, Susanna
AU - Lo Vecchio, Andrea
AU - Govoni, Maria Rita
AU - Vallongo, Cristina
AU - Dodi, Icilio
AU - Castagnola, Elio
AU - Rossi, Nadia
AU - Valentini, Piero
AU - Cardinale, Fabio
AU - Salvini, Filippo
AU - Bona, Gianni
AU - Bossi, Grazia
AU - Olivieri, Alma Nunzia
AU - Russo, Fiorella
AU - Fossali, Emilio
AU - Bottone, Gabriella
AU - Dellepiane, Marta
AU - De Martino, Maurizio
AU - Villani, Alberto
AU - Galli, Luisa
PY - 2018
Y1 - 2018
N2 - Background: Acute/subacute haematogenous osteomyelitis (AHOM/SAHOM) are potentially devastating diseases. Updated information about the epidemiology, management and outcome of AHOM/SAHOM is needed to minimize the risk of complications and sequelae. Methods: A multicenter study was performed to evaluate retrospectively the management and outcome of AHOM/SAHOM in Italy. Data from children aged >1 month, and hospitalized between 2010 and 2016, in 19 pediatric centers, were analyzed. Results: 300 children with AHOM and 98 with SAHOM were included. Median age was 6.0 years (IQR: 2.0–11.0). No clinical difference was observed with the exception of fever at onset (63.0% vs. 42.9%; P < 0.0001), and a more common spinal involvement in SAHOM (6.7% vs 20.4%; P < 0.001). Fifty-Eight Staphylococcus aureus strains were isolated; 5 (8.6%) were MRSA. No Kingella kingae infection was documented. No different risk for complication/sequela was observed between AHOM and SAHOM (38.3% vs. 34.7%; OR:0.85; 95%CI: 0.53–1.38; P = 0.518). Duration and type of antibiotic therapy were not associated with risk of complication/sequelae. Conclusion: AHOM and SAHOM displayed some differences, however occurrence and risk factors for complications and sequelae are similar, and the same empiric treatment might be recommended.
AB - Background: Acute/subacute haematogenous osteomyelitis (AHOM/SAHOM) are potentially devastating diseases. Updated information about the epidemiology, management and outcome of AHOM/SAHOM is needed to minimize the risk of complications and sequelae. Methods: A multicenter study was performed to evaluate retrospectively the management and outcome of AHOM/SAHOM in Italy. Data from children aged >1 month, and hospitalized between 2010 and 2016, in 19 pediatric centers, were analyzed. Results: 300 children with AHOM and 98 with SAHOM were included. Median age was 6.0 years (IQR: 2.0–11.0). No clinical difference was observed with the exception of fever at onset (63.0% vs. 42.9%; P < 0.0001), and a more common spinal involvement in SAHOM (6.7% vs 20.4%; P < 0.001). Fifty-Eight Staphylococcus aureus strains were isolated; 5 (8.6%) were MRSA. No Kingella kingae infection was documented. No different risk for complication/sequela was observed between AHOM and SAHOM (38.3% vs. 34.7%; OR:0.85; 95%CI: 0.53–1.38; P = 0.518). Duration and type of antibiotic therapy were not associated with risk of complication/sequelae. Conclusion: AHOM and SAHOM displayed some differences, however occurrence and risk factors for complications and sequelae are similar, and the same empiric treatment might be recommended.
KW - Acute haematogenous osteomyelitis
KW - children
KW - risk factors
KW - Staphylococcus aureus
KW - subacute haematogenous osteomyelitis
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U2 - 10.1080/14787210.2018.1453357
DO - 10.1080/14787210.2018.1453357
M3 - Article
AN - SCOPUS:85044504413
VL - 16
SP - 351
EP - 358
JO - Expert Review of Anti-Infective Therapy
JF - Expert Review of Anti-Infective Therapy
SN - 1478-7210
IS - 4
ER -