TY - JOUR
T1 - Risk factors for a first generalized tonic-cloic seizure in adult life
AU - Leone, M.
AU - Bottacchi, E.
AU - Beghi, E.
AU - Morgando, E.
AU - Mutani, R.
AU - Cremo, R.
AU - Ravagli Ceroni, L.
AU - Floriani, I.
PY - 2002/9
Y1 - 2002/9
N2 - To evaluate risk factors for a first generalized tonic-clonic seizure (GTCS) in adults (≥15 years), we performed a multicenter, case-control study involving eleven first-referral neurological departments in north-western Italy. The study enrolled 278 patients with a first GTCS, and 556 age- and sex-matched hospital controls. Cases and controls were interviewed through a questionnaire (inter-rater and index-proxy agreement varied between 75% and 100% for the different questions). Risk factors significantly associated with a first GTCS were: severe head trauma (odds ratio 9.9; 95% confidence limits 2.0-67.1), siblings with seizures (5.7; 1.7-21.4), alcohol intake >50 grams/day (4.9; 3.1-7.9), history of stroke (3.8; 1.8-8.0), complications of delivery (2.7; 1.5-5.1), other relatives with seizures (2.4; 1.3-4.6), sleep deprivation (2.4; 1.4-4.1), low gestational age (1.9; 1.1-3.4), mild-moderate head trauma (1.8; 1.2-3.0), and low birth weight (1.6; 1.0-2.7). Genetic and late acquired factors and life habits are major risk factors for a first GTCS in adults, while pre- and perinatal events play only a minor role.
AB - To evaluate risk factors for a first generalized tonic-clonic seizure (GTCS) in adults (≥15 years), we performed a multicenter, case-control study involving eleven first-referral neurological departments in north-western Italy. The study enrolled 278 patients with a first GTCS, and 556 age- and sex-matched hospital controls. Cases and controls were interviewed through a questionnaire (inter-rater and index-proxy agreement varied between 75% and 100% for the different questions). Risk factors significantly associated with a first GTCS were: severe head trauma (odds ratio 9.9; 95% confidence limits 2.0-67.1), siblings with seizures (5.7; 1.7-21.4), alcohol intake >50 grams/day (4.9; 3.1-7.9), history of stroke (3.8; 1.8-8.0), complications of delivery (2.7; 1.5-5.1), other relatives with seizures (2.4; 1.3-4.6), sleep deprivation (2.4; 1.4-4.1), low gestational age (1.9; 1.1-3.4), mild-moderate head trauma (1.8; 1.2-3.0), and low birth weight (1.6; 1.0-2.7). Genetic and late acquired factors and life habits are major risk factors for a first GTCS in adults, while pre- and perinatal events play only a minor role.
KW - Alcohol drinking
KW - Case control
KW - Epilepsy
KW - Reliability
KW - Risk factors
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U2 - 10.1007/s100720200034
DO - 10.1007/s100720200034
M3 - Article
C2 - 12391493
AN - SCOPUS:18744397515
VL - 23
SP - 99
EP - 106
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 3
ER -