Risk factors for a first thrombotic event in antiphospholipid antibody carriers: A prospective multicentre follow-up study

Amelia Ruffatti, Teresa Del Ross, Manuela Ciprian, Maria T. Bertero, Salvatore Sciascia, Salvatore Scarpato, Carlomaurizio Montecucco, Silvia Rossi, Paola Caramaschi, Domenico Biasi, Andrea Doria, Mariaelisa Rampudda, Monica Nuzzo, Fabio Fischetti, Ugo Picillo, Antonio Brucato, Elisa Salvan, Vittorio Pengo, Pierluigi Meroni, Tincani Angela Tincani

Research output: Contribution to journalArticle

Abstract

Objectives To assess risk factors for a first thrombotic event in confirmed antiphospholipid (aPL) antibody carriers and to evaluate the efficacy of prophylactic treatments. Methods Inclusion criteria were age 18-65 years, no history of thrombosis and two consecutive positive aPL results. Demographic, laboratory and clinical parameters were collected at enrolment, once a year during the follow-up and at the time of the thrombotic event, whenever that occurred. Results 258 subjects were prospectively observed between October 2004 and October 2008. The mean±SD follow-up was 35.0±11.9 months (range 1-48). A first thrombotic event (9 venous, 4 arterial and 1 transient ischaemic attack) occurred in 14 subjects (5.4%, annual incidence rate 1.86%). Hypertension and lupus anticoagulant (LA) were significantly predictive of thrombosis (both at p

Original languageEnglish
Pages (from-to)1083-1086
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume70
Issue number6
DOIs
Publication statusPublished - Jun 2011

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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    Ruffatti, A., Del Ross, T., Ciprian, M., Bertero, M. T., Sciascia, S., Scarpato, S., Montecucco, C., Rossi, S., Caramaschi, P., Biasi, D., Doria, A., Rampudda, M., Nuzzo, M., Fischetti, F., Picillo, U., Brucato, A., Salvan, E., Pengo, V., Meroni, P., & Angela Tincani, T. (2011). Risk factors for a first thrombotic event in antiphospholipid antibody carriers: A prospective multicentre follow-up study. Annals of the Rheumatic Diseases, 70(6), 1083-1086. https://doi.org/10.1136/ard.2010.142042