Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital Long-QT syndrome

Ilan Goldenberg, Arthur J. Moss, Derick R. Peterson, Scott McNitt, Wojciech Zareba, Mark L. Andrews, Jennifer L. Robinson, Emanuela H. Locati, Michael J. Ackerman, Jesaia Benhorin, Elizabeth S. Kaufman, Carlo Napolitano, Silvia G. Priori, Ming Qi, Peter J. Schwartz, Jeffrey A. Towbin, G. Michael Vincent, Li Zhang

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Background-The congenital long-QT syndrome (LQTS) is an important cause of sudden cardiac death in children without structural heart disease. However, specific risk factors for life-threatening cardiac events in children with this genetic disorder have not been identified. Methods and Results-Cox proportional-hazards regression modeling was used to identify risk factors for aborted cardiac arrest or sudden cardiac death in 3015 LQTS children from the International LQTS Registry who were followed up from 1 through 12 years of age. The cumulative probability of the combined end point was significantly higher in boys (5%) than in girls (1%; P500 ms (hazard ratio [HR]; 2.72; 95% confidence interval [CI], 1.50 to 4.92; P=0.001) and prior syncope (recent syncope [

Original languageEnglish
Pages (from-to)2184-2191
Number of pages8
JournalCirculation
Volume117
Issue number17
DOIs
Publication statusPublished - Apr 29 2008

Fingerprint

Long QT Syndrome
Sudden Cardiac Death
Heart Arrest
Syncope
Inborn Genetic Diseases
Registries
Heart Diseases
Confidence Intervals

Keywords

  • Death
  • Long-QT syndrome
  • Risk factors
  • Sudden

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Goldenberg, I., Moss, A. J., Peterson, D. R., McNitt, S., Zareba, W., Andrews, M. L., ... Zhang, L. (2008). Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital Long-QT syndrome. Circulation, 117(17), 2184-2191. https://doi.org/10.1161/CIRCULATIONAHA.107.701243

Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital Long-QT syndrome. / Goldenberg, Ilan; Moss, Arthur J.; Peterson, Derick R.; McNitt, Scott; Zareba, Wojciech; Andrews, Mark L.; Robinson, Jennifer L.; Locati, Emanuela H.; Ackerman, Michael J.; Benhorin, Jesaia; Kaufman, Elizabeth S.; Napolitano, Carlo; Priori, Silvia G.; Qi, Ming; Schwartz, Peter J.; Towbin, Jeffrey A.; Vincent, G. Michael; Zhang, Li.

In: Circulation, Vol. 117, No. 17, 29.04.2008, p. 2184-2191.

Research output: Contribution to journalArticle

Goldenberg, I, Moss, AJ, Peterson, DR, McNitt, S, Zareba, W, Andrews, ML, Robinson, JL, Locati, EH, Ackerman, MJ, Benhorin, J, Kaufman, ES, Napolitano, C, Priori, SG, Qi, M, Schwartz, PJ, Towbin, JA, Vincent, GM & Zhang, L 2008, 'Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital Long-QT syndrome', Circulation, vol. 117, no. 17, pp. 2184-2191. https://doi.org/10.1161/CIRCULATIONAHA.107.701243
Goldenberg, Ilan ; Moss, Arthur J. ; Peterson, Derick R. ; McNitt, Scott ; Zareba, Wojciech ; Andrews, Mark L. ; Robinson, Jennifer L. ; Locati, Emanuela H. ; Ackerman, Michael J. ; Benhorin, Jesaia ; Kaufman, Elizabeth S. ; Napolitano, Carlo ; Priori, Silvia G. ; Qi, Ming ; Schwartz, Peter J. ; Towbin, Jeffrey A. ; Vincent, G. Michael ; Zhang, Li. / Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital Long-QT syndrome. In: Circulation. 2008 ; Vol. 117, No. 17. pp. 2184-2191.
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