Risk factors for acute kidney injury after surgery of the thoracic aorta using antegrade selective cerebral perfusion and moderate hypothermia

Davide Pacini, Antonio Pantaleo, Luca Di Marco, Alessandro Leone, Giuseppe Barberio, Alessandro Parolari, Giuliano Jafrancesco, Roberto Di Bartolomeo

Research output: Contribution to journalArticlepeer-review

Abstract

Background The development of acute kidney injury (AKI) in cardiac surgery is associated with increased morbidity and mortality. The aim of the study was to assess the incidence and risk factors for AKI after thoracic aorta surgery, using antegrade selective cerebral perfusion (ASCP) and moderate hypothermia. Methods We reviewed 641 patients undergoing thoracic aortic surgery, using ASCP and moderate hypothermia, from November 1996 to December 2012. Patient preoperative, intraoperative, and postoperative variables were evaluated for association with AKI with logistic regression analysis. Models including all variables and models, after the sequential removal of postoperative, and both postoperative and intraoperative variables, were assessed using receiver operating characteristic analysis. Results The mean age of the patients was 62.9 years, and 194 patients (30%) were women. The overall incidence of AKI was 19.0%. In-hospital mortality was significantly higher in the AKI group (33.6% vs 6.7%; P

Original languageEnglish
Pages (from-to)127-133e1
JournalJournal of Thoracic and Cardiovascular Surgery
Volume150
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • cerebral protection
  • Key Words acute kidney injury
  • logistic regression analysis
  • ROC analysis
  • thoracic aorta surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

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