Risk factors for adult soft tissue sarcoma in northern Italy

S. Franceschi, D. Serraino

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The role of several potential risk factors in the etiology of soft-tissue sarcoma (STS) was examined in a hospital-based case-control study, conducted in the Friuli-Venezia Giulia region, northeast Italy, between 1985 and 1991. A total of 93 STS cases (53 males and 40 females, median age: 52 years) and of 721 controls (371 males and 350 females, median age: 54 years) were interviewed. Significant increased risks were associated with a history of herpes zoster infection (odds ratio (OR): 2.3, 95% confidence interval (CI): 1.1-4.9), chicken-pox (OR: 2.1, 95% CI: 1.2-4.1) and mumps (OR: 2.0, 95% CI: 1.1-3.8). None of the other medical conditions investigated - socio-economic and anthropometric indicators, tobacco smoking, consumption of alcoholic beverages, coffee and tea - seemed to affect STS risk. No risk elevation was found in subjects employed in agriculture (OR - for > 10 years employment = 0.8, 95% CI: 1.4-1.5), nor in those who reported exposure to pesticides or herbicides (OR = 0.4, 95% CI: 0.1-1.2). Workers who reported exposure to chemical agents or to benzene or other solvents for more than 10 years had, respectively, a 1.8-fold (95% CI: 0.7-4.4) and a 2.2-fold (95% CI: 0.9-5.5) higher risk of developing STS.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalAnnals of Oncology
Volume3
Issue numberSUPPL. 2
Publication statusPublished - 1992

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Sarcoma
Italy
Confidence Intervals
Odds Ratio
Alcoholic Beverages
Mumps
Chickenpox
Coffee
Herpes Zoster
Tobacco Use
Herbicides
Tea
Benzene
Agriculture
Pesticides
Case-Control Studies
Smoking
Economics
Infection

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Risk factors for adult soft tissue sarcoma in northern Italy. / Franceschi, S.; Serraino, D.

In: Annals of Oncology, Vol. 3, No. SUPPL. 2, 1992, p. 85-88.

Research output: Contribution to journalArticle

Franceschi, S. ; Serraino, D. / Risk factors for adult soft tissue sarcoma in northern Italy. In: Annals of Oncology. 1992 ; Vol. 3, No. SUPPL. 2. pp. 85-88.
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abstract = "The role of several potential risk factors in the etiology of soft-tissue sarcoma (STS) was examined in a hospital-based case-control study, conducted in the Friuli-Venezia Giulia region, northeast Italy, between 1985 and 1991. A total of 93 STS cases (53 males and 40 females, median age: 52 years) and of 721 controls (371 males and 350 females, median age: 54 years) were interviewed. Significant increased risks were associated with a history of herpes zoster infection (odds ratio (OR): 2.3, 95{\%} confidence interval (CI): 1.1-4.9), chicken-pox (OR: 2.1, 95{\%} CI: 1.2-4.1) and mumps (OR: 2.0, 95{\%} CI: 1.1-3.8). None of the other medical conditions investigated - socio-economic and anthropometric indicators, tobacco smoking, consumption of alcoholic beverages, coffee and tea - seemed to affect STS risk. No risk elevation was found in subjects employed in agriculture (OR - for > 10 years employment = 0.8, 95{\%} CI: 1.4-1.5), nor in those who reported exposure to pesticides or herbicides (OR = 0.4, 95{\%} CI: 0.1-1.2). Workers who reported exposure to chemical agents or to benzene or other solvents for more than 10 years had, respectively, a 1.8-fold (95{\%} CI: 0.7-4.4) and a 2.2-fold (95{\%} CI: 0.9-5.5) higher risk of developing STS.",
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