Risk factors for breast cancer: Pooled results from three Italian case-control studies

Eva Negri, Carlo La Vecchia, Paolo Bruzzi, Gabriella Dardanoni, Adriano Decarli, Domenico Palli, Fabio Parazzini, Marco Rosselli Del Turco

Research output: Contribution to journalArticlepeer-review


Negri, E. ("Mario Negri" Institute for Pharmacological Research, Via Eritrea, 62, 20157 Milan, Italy), C. La Vecchia, P. Bruzzi, G. Dardanoni, A. Decarli, D. Palli, F. Parazzini, and M. Rosselli del Turco. Risk factors for breast cancer pooled results from three Italian case-control studies. Am J Epidemiol 1988; 128:1207-15.The role of menstrual and reproductive factors, family history, and body weight in the epidemiology of breast cancer has been reassessed in a meta-analysis of three large case-control studies of breast cancer from several Italian regions, for a total data set of 4,072 cases and 4,099 controls. Multiple logistic regression equations were used to obtain relative risks adjusted for study, center, age, and various combinations of risk factors considered. Relative to women with men-arche at age 15 or over, those with earlier menarche had a 20-30% higher breast cancer risk. However, there was no tendency for the risk to increase with lower age at menarche, and the association with menarche was stronger at younger age. The risk of breast cancer was directly related to age at menopause (relative risk (RR)=0.7 for 50 years), age at first live birth (RR =1.8 for >28 years vs.

Original languageEnglish
Pages (from-to)1207-1215
Number of pages9
JournalAmerican Journal of Epidemiology
Issue number6
Publication statusPublished - Dec 1988


  • Body weight
  • Breast neoplasms
  • Menarche
  • Menopause
  • Parity

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology


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