Risk factors for bronchiolitis hospitalization during the first year of life in a multicenter Italian birth cohort

Marcello Lanari, Federica Prinelli, Fulvio Adorni, Simona Di Santo, Silvia Vandini, Michela Silvestri, Massimo Musicco

Research output: Contribution to journalArticle

Abstract

Background: Respiratory Syncytial Virus (RSV) is one of the main causes of respiratory infections during the first year of life. Very premature infants may contract more severe diseases and 'late preterm infants' may also be more susceptible to the infection. The aim of this study is to evaluate the risk factors for hospitalization during the first year of life in children born at different gestational ages in Italy. Methods: A cohort of 33-34 weeks gestational age (wGA) newborns matched by sex and age with two cohort of newborns born at 35-37 wGA and∈>∈37 wGA were enrolled in this study for a three-year period (2009-2012). Hospitalization for bronchiolitis (ICD-9 code 466.1) during the first year of life was assessed through phone interview at the end of the RSV season (November-March) and at the completion of the first year of life. Results: The study enrolled 2314 newborns, of which 2210 (95.5 %) had a one year follow-up and were included in the analysis; 120 (5.4 %) were hospitalized during the first year of life for bronchiolitis. Children born at 33-34 wGA had a higher hospitalization rate compared to the two other groups. The multivariate analysis carried out on the entire population associated the following factors with higher rates for bronchiolitis hospitalization: male gender; prenatal treatment with corticosteroids; prenatal exposure to maternal smoking; singleton delivery; respiratory diseases in neonatal period; surfactant therapy; lack of breastfeeding; siblings

Original languageEnglish
Article number40
JournalItalian Journal of Pediatrics
Volume41
Issue number1
DOIs
Publication statusPublished - May 26 2015

Keywords

  • Bronchiolitis
  • Children
  • Hospitalization
  • Palivizumab
  • Prophylaxis
  • Respiratory syncytial virus
  • Risk factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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