Risk factors for chronic renal dysfunction in lung transplant recipients

Ciro Esposito, Andreana De Mauri, Patrizio Vitulo, Tiberio Oggionni, Flavia Cornacchia, Rossella Valentino, Fabrizio Grosjean, Massimo Torreggiani, Antonio Dal Canton

Research output: Contribution to journalArticle

Abstract

Several factors predispose to renal dysfunction (RD), a common complication of solid organ transplants. We evaluated the impact of clinical and laboratory parameters on the decline of renal function in lung and heart-lung transplant recipients. We enrolled 45 patients who survived more than 6 months after transplantation, had normal renal function and urinalysis before the surgery. The prognostic value of variables for the occurrence of RD was calculated by univariate analysis. Thirty patients developed RD, defined as doubling of serum creatinine or creatinine steadily >1.5 mg/dL after a median time of 12 months. Serum creatinine above 0.9 mg/dL during the month preceding lung transplant, systolic blood pressure above 130 mmHg, and pretransplant idiopathic pulmonary hypertension were significantly associated with the development of RD. Our findings indicate that increased systolic blood pressure, reduced glomerular filtration rate, and idiopathic pulmonary hypertension are risk factors for chronic RD in lung transplant recipients.

Original languageEnglish
Pages (from-to)1701-1703
Number of pages3
JournalTransplantation
Volume84
Issue number12
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Blood pressure
  • Creatinine
  • Renal function
  • Risk factors
  • Transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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