Fattori di rischio per l'ipertensione polmonare cronica tromboembolica e il "Pavia Pulmonary Endarterectomy Program"

Translated title of the contribution: Risk factors for chronic thromboembolic pulmonary hypertension and the "Pavia Pulmonary Endarterectomy Program"

Franco Piovella, Andrea M. D'Armini, Marisa Barone, Chiara Piovella, Marco Morsolini, Victor F. Tapson

Research output: Contribution to journalArticle

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, progressive and lethal disease for which there is no effective medical therapy. Pulmonary endarterectomy (PEA) is therefore the treatment of choice. Perioperative mortality rates range from 5 to 24% with significant variation in the hemodynamic improvement reported. In view of the high risk of PTE, careful pre- and post-operative management is essential for a successful outcome following PEA and patients should be referred to centers with experience that provide a multidisciplinary approach. In 1994 the "Pavia Pulmonary Endarterectomy Program" was established at the Fondazione IRCCS Policlinico San Matteo - University of Pavia, Italy, in which members of a multidisciplinary team involving 11 units work in close collaboration with the aim to increase experience in the challenging problems these patients present in the evaluative, surgical, and post-operative phases of their care. Between April 1994 and August 2007, 165 PEAs have been performed in 162 patients. This review focuses on the pathogenesis and risk factors of the disease and presents insights gained from the experience of this steadily growing center.

Original languageItalian
Pages (from-to)440-444
Number of pages5
JournalMultidisciplinary Respiratory Medicine
Volume3
Issue number6
Publication statusPublished - 2008

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Endarterectomy
Pulmonary Hypertension
Lung
Italy
Hemodynamics
Mortality
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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title = "Fattori di rischio per l'ipertensione polmonare cronica tromboembolica e il {"}Pavia Pulmonary Endarterectomy Program{"}",
abstract = "Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, progressive and lethal disease for which there is no effective medical therapy. Pulmonary endarterectomy (PEA) is therefore the treatment of choice. Perioperative mortality rates range from 5 to 24{\%} with significant variation in the hemodynamic improvement reported. In view of the high risk of PTE, careful pre- and post-operative management is essential for a successful outcome following PEA and patients should be referred to centers with experience that provide a multidisciplinary approach. In 1994 the {"}Pavia Pulmonary Endarterectomy Program{"} was established at the Fondazione IRCCS Policlinico San Matteo - University of Pavia, Italy, in which members of a multidisciplinary team involving 11 units work in close collaboration with the aim to increase experience in the challenging problems these patients present in the evaluative, surgical, and post-operative phases of their care. Between April 1994 and August 2007, 165 PEAs have been performed in 162 patients. This review focuses on the pathogenesis and risk factors of the disease and presents insights gained from the experience of this steadily growing center.",
keywords = "Chronic thromboembolic pulmonary hypertension, Pulmonary endarterectomy, Risk factors, Surgical intervention",
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AU - Piovella, Franco

AU - D'Armini, Andrea M.

AU - Barone, Marisa

AU - Piovella, Chiara

AU - Morsolini, Marco

AU - Tapson, Victor F.

PY - 2008

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N2 - Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, progressive and lethal disease for which there is no effective medical therapy. Pulmonary endarterectomy (PEA) is therefore the treatment of choice. Perioperative mortality rates range from 5 to 24% with significant variation in the hemodynamic improvement reported. In view of the high risk of PTE, careful pre- and post-operative management is essential for a successful outcome following PEA and patients should be referred to centers with experience that provide a multidisciplinary approach. In 1994 the "Pavia Pulmonary Endarterectomy Program" was established at the Fondazione IRCCS Policlinico San Matteo - University of Pavia, Italy, in which members of a multidisciplinary team involving 11 units work in close collaboration with the aim to increase experience in the challenging problems these patients present in the evaluative, surgical, and post-operative phases of their care. Between April 1994 and August 2007, 165 PEAs have been performed in 162 patients. This review focuses on the pathogenesis and risk factors of the disease and presents insights gained from the experience of this steadily growing center.

AB - Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, progressive and lethal disease for which there is no effective medical therapy. Pulmonary endarterectomy (PEA) is therefore the treatment of choice. Perioperative mortality rates range from 5 to 24% with significant variation in the hemodynamic improvement reported. In view of the high risk of PTE, careful pre- and post-operative management is essential for a successful outcome following PEA and patients should be referred to centers with experience that provide a multidisciplinary approach. In 1994 the "Pavia Pulmonary Endarterectomy Program" was established at the Fondazione IRCCS Policlinico San Matteo - University of Pavia, Italy, in which members of a multidisciplinary team involving 11 units work in close collaboration with the aim to increase experience in the challenging problems these patients present in the evaluative, surgical, and post-operative phases of their care. Between April 1994 and August 2007, 165 PEAs have been performed in 162 patients. This review focuses on the pathogenesis and risk factors of the disease and presents insights gained from the experience of this steadily growing center.

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