Risk factors for classical Kaposi's sarcoma

James J. Goedert, Francesco Vitale, Carmela Lauria, Diego Serraino, Mario Tamburini, Maurizio Montella, Angelo Messina, Elizabeth E. Brown, Giovanni Rezza, Lorenzo Gafà, Nino Romano

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background: Classical Kaposi's sarcoma (KS) is a malignancy of lymphatic endothelial skin cells. Although all forms of KS are associated with the KS-associated herpesvirus (KSHV), classical KS occurs in a small fraction of KSHV-infected people. We sought to identify risk factors for classical KS in KSHV-infected individuals. Methods: Lifestyle and medical history data from case patients with biopsyproven non-AIDS (non-acquired immunodeficiency syndrome) KS in Italy were compared by logistic regression analysis with data from population-based KSHV-seropositive control subjects of comparable age and sex. After KSHV immunofluorescence testing, randomly selected patients on the rosters of local physicians were identified as control subjects. Risk of KS was estimated by odds ratios (ORs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results: From April 13, 1998, through October 8, 2001, we enrolled 141 classical KS case patients and 192 KSHV-seropositive control subjects of similar age (mean = 72 years for case patients and 73 years for control subjects) and sex (30% female case patients and 35% female control subjects). The strongest association was a reduced risk of KS with cigarette smoking (OR = 0.25, 95% CI = 0.14 to 0.45). Cigarette smoking intensity and duration could be evaluated for men, among whom the risk for KS was inversely related to the amount of cumulative smoking (Ptrend

Original languageEnglish
Pages (from-to)1712-1718
Number of pages7
JournalJournal of the National Cancer Institute
Volume94
Issue number22
Publication statusPublished - Nov 20 2002

Fingerprint

Kaposi's Sarcoma
Herpesviridae
Smoking
Odds Ratio
Confidence Intervals
Human Herpesvirus 8
Italy
Fluorescent Antibody Technique
Life Style
Endothelial Cells
Logistic Models
Regression Analysis
Physicians
Skin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Goedert, J. J., Vitale, F., Lauria, C., Serraino, D., Tamburini, M., Montella, M., ... Romano, N. (2002). Risk factors for classical Kaposi's sarcoma. Journal of the National Cancer Institute, 94(22), 1712-1718.

Risk factors for classical Kaposi's sarcoma. / Goedert, James J.; Vitale, Francesco; Lauria, Carmela; Serraino, Diego; Tamburini, Mario; Montella, Maurizio; Messina, Angelo; Brown, Elizabeth E.; Rezza, Giovanni; Gafà, Lorenzo; Romano, Nino.

In: Journal of the National Cancer Institute, Vol. 94, No. 22, 20.11.2002, p. 1712-1718.

Research output: Contribution to journalArticle

Goedert, JJ, Vitale, F, Lauria, C, Serraino, D, Tamburini, M, Montella, M, Messina, A, Brown, EE, Rezza, G, Gafà, L & Romano, N 2002, 'Risk factors for classical Kaposi's sarcoma', Journal of the National Cancer Institute, vol. 94, no. 22, pp. 1712-1718.
Goedert JJ, Vitale F, Lauria C, Serraino D, Tamburini M, Montella M et al. Risk factors for classical Kaposi's sarcoma. Journal of the National Cancer Institute. 2002 Nov 20;94(22):1712-1718.
Goedert, James J. ; Vitale, Francesco ; Lauria, Carmela ; Serraino, Diego ; Tamburini, Mario ; Montella, Maurizio ; Messina, Angelo ; Brown, Elizabeth E. ; Rezza, Giovanni ; Gafà, Lorenzo ; Romano, Nino. / Risk factors for classical Kaposi's sarcoma. In: Journal of the National Cancer Institute. 2002 ; Vol. 94, No. 22. pp. 1712-1718.
@article{591bf3c3ef0c492a8d20f8b22a19f54a,
title = "Risk factors for classical Kaposi's sarcoma",
abstract = "Background: Classical Kaposi's sarcoma (KS) is a malignancy of lymphatic endothelial skin cells. Although all forms of KS are associated with the KS-associated herpesvirus (KSHV), classical KS occurs in a small fraction of KSHV-infected people. We sought to identify risk factors for classical KS in KSHV-infected individuals. Methods: Lifestyle and medical history data from case patients with biopsyproven non-AIDS (non-acquired immunodeficiency syndrome) KS in Italy were compared by logistic regression analysis with data from population-based KSHV-seropositive control subjects of comparable age and sex. After KSHV immunofluorescence testing, randomly selected patients on the rosters of local physicians were identified as control subjects. Risk of KS was estimated by odds ratios (ORs) and 95{\%} confidence intervals (CIs). All statistical tests were two-sided. Results: From April 13, 1998, through October 8, 2001, we enrolled 141 classical KS case patients and 192 KSHV-seropositive control subjects of similar age (mean = 72 years for case patients and 73 years for control subjects) and sex (30{\%} female case patients and 35{\%} female control subjects). The strongest association was a reduced risk of KS with cigarette smoking (OR = 0.25, 95{\%} CI = 0.14 to 0.45). Cigarette smoking intensity and duration could be evaluated for men, among whom the risk for KS was inversely related to the amount of cumulative smoking (Ptrend",
author = "Goedert, {James J.} and Francesco Vitale and Carmela Lauria and Diego Serraino and Mario Tamburini and Maurizio Montella and Angelo Messina and Brown, {Elizabeth E.} and Giovanni Rezza and Lorenzo Gaf{\`a} and Nino Romano",
year = "2002",
month = "11",
day = "20",
language = "English",
volume = "94",
pages = "1712--1718",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "22",

}

TY - JOUR

T1 - Risk factors for classical Kaposi's sarcoma

AU - Goedert, James J.

AU - Vitale, Francesco

AU - Lauria, Carmela

AU - Serraino, Diego

AU - Tamburini, Mario

AU - Montella, Maurizio

AU - Messina, Angelo

AU - Brown, Elizabeth E.

AU - Rezza, Giovanni

AU - Gafà, Lorenzo

AU - Romano, Nino

PY - 2002/11/20

Y1 - 2002/11/20

N2 - Background: Classical Kaposi's sarcoma (KS) is a malignancy of lymphatic endothelial skin cells. Although all forms of KS are associated with the KS-associated herpesvirus (KSHV), classical KS occurs in a small fraction of KSHV-infected people. We sought to identify risk factors for classical KS in KSHV-infected individuals. Methods: Lifestyle and medical history data from case patients with biopsyproven non-AIDS (non-acquired immunodeficiency syndrome) KS in Italy were compared by logistic regression analysis with data from population-based KSHV-seropositive control subjects of comparable age and sex. After KSHV immunofluorescence testing, randomly selected patients on the rosters of local physicians were identified as control subjects. Risk of KS was estimated by odds ratios (ORs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results: From April 13, 1998, through October 8, 2001, we enrolled 141 classical KS case patients and 192 KSHV-seropositive control subjects of similar age (mean = 72 years for case patients and 73 years for control subjects) and sex (30% female case patients and 35% female control subjects). The strongest association was a reduced risk of KS with cigarette smoking (OR = 0.25, 95% CI = 0.14 to 0.45). Cigarette smoking intensity and duration could be evaluated for men, among whom the risk for KS was inversely related to the amount of cumulative smoking (Ptrend

AB - Background: Classical Kaposi's sarcoma (KS) is a malignancy of lymphatic endothelial skin cells. Although all forms of KS are associated with the KS-associated herpesvirus (KSHV), classical KS occurs in a small fraction of KSHV-infected people. We sought to identify risk factors for classical KS in KSHV-infected individuals. Methods: Lifestyle and medical history data from case patients with biopsyproven non-AIDS (non-acquired immunodeficiency syndrome) KS in Italy were compared by logistic regression analysis with data from population-based KSHV-seropositive control subjects of comparable age and sex. After KSHV immunofluorescence testing, randomly selected patients on the rosters of local physicians were identified as control subjects. Risk of KS was estimated by odds ratios (ORs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results: From April 13, 1998, through October 8, 2001, we enrolled 141 classical KS case patients and 192 KSHV-seropositive control subjects of similar age (mean = 72 years for case patients and 73 years for control subjects) and sex (30% female case patients and 35% female control subjects). The strongest association was a reduced risk of KS with cigarette smoking (OR = 0.25, 95% CI = 0.14 to 0.45). Cigarette smoking intensity and duration could be evaluated for men, among whom the risk for KS was inversely related to the amount of cumulative smoking (Ptrend

UR - http://www.scopus.com/inward/record.url?scp=0037146222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037146222&partnerID=8YFLogxK

M3 - Article

C2 - 12441327

AN - SCOPUS:0037146222

VL - 94

SP - 1712

EP - 1718

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 22

ER -