Risk factors for disease progression in advanced jejunoileal neuroendocrine tumors

Francesco Panzuto, Davide Campana, Nicola Fazio, Maria Pia Brizzi, Letizia Boninsegna, Francesca Nori, Giovanni Di Meglio, Gabriele Capurso, Aldo Scarpa, Luigi Dogliotti, Filippo De Braud, Paola Tomassetti, Gianfranco Delle Fave, Massimo Falconi

Research output: Contribution to journalArticle

Abstract

Background: Knowledge of clinical course in advanced jejunoileal neuroendocrine tumors (NETs) is poor. Aim: To investigate progression-free survival (PFS), overall survival (OS), and possible predictors for disease progression (DP) in advanced jejunoileal NETs. Patients and Methods: We carried out a multicenter, retrospective analysis of incoming patients with sporadic advanced jejunoileal NETs. PFS and OS were assessed by Kaplan-Meier analysis. Risk factors for progression were analyzed by the Cox proportional hazards method. Results: Of the 114 patients enrolled, 46.5% had functioning tumors, 93.9% had stage IV disease, and 57.3 and 42.7% were G1 and G2 tumors, respectively. During a median follow-up of 48 months (interquartile range 29-84 months), DP occurred in 61.4% of patients, after 19 months (interquartile range 10-41 months) from diagnosis. Median PFS was 36 months. The 2-year and 5-year PFS were 59 and 33%, respectively, while 5-year OS was 77.5%. Ki67 was the sole strong independent risk factor for unfavorable outcome according to multivariate analysis, being significantly associated with both PFS and OS. Conclusions: DP occurred in the majority of patients with advanced jejunoileal NETs, with median PFS being 36 months. Ki67 was a significant predictor of DP and should be considered in determining appropriate treatments and planning follow-up for these patients.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalNeuroendocrinology
Volume96
Issue number1
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Carcinoid
  • Midgut
  • Neuroendocrine tumors
  • Progression-free survival
  • Risk factors

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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    Panzuto, F., Campana, D., Fazio, N., Brizzi, M. P., Boninsegna, L., Nori, F., Di Meglio, G., Capurso, G., Scarpa, A., Dogliotti, L., De Braud, F., Tomassetti, P., Delle Fave, G., & Falconi, M. (2012). Risk factors for disease progression in advanced jejunoileal neuroendocrine tumors. Neuroendocrinology, 96(1), 32-40. https://doi.org/10.1159/000334038