Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis

Robert R. McWilliams, Patrick Maisonneuve, William R. Bamlet, Gloria M. Petersen, Donghui Li, Harvey A. Risch, Herbert Yu, Elizabeth T H Fontham, Brian Luckett, Cristina Bosetti, Eva Vanna Lorenza Negri, Carlo La Vecchia, Renato Talamini, H. Bas Bueno De Mesquita, Paige M. Bracci, Steven Gallinger, Rachel E. Neale, Albert B. Lowenfels

Research output: Contribution to journalArticle

Abstract

Objectives While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. Methods We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age-and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. Results Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose-and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09). Conclusions The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalPancreas
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

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Pancreatic Neoplasms
Adenocarcinoma
Alcohols
Obesity
Smoking
Odds Ratio
Confidence Intervals
Pancreatitis
Case-Control Studies
Diabetes Mellitus
Logistic Models
Regression Analysis

Keywords

  • alcohol
  • early onset
  • obesity
  • pancreatic cancer
  • smoking
  • very early onset

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma : A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis. / McWilliams, Robert R.; Maisonneuve, Patrick; Bamlet, William R.; Petersen, Gloria M.; Li, Donghui; Risch, Harvey A.; Yu, Herbert; Fontham, Elizabeth T H; Luckett, Brian; Bosetti, Cristina; Negri, Eva Vanna Lorenza; La Vecchia, Carlo; Talamini, Renato; De Mesquita, H. Bas Bueno; Bracci, Paige M.; Gallinger, Steven; Neale, Rachel E.; Lowenfels, Albert B.

In: Pancreas, Vol. 45, No. 2, 01.02.2016, p. 311-316.

Research output: Contribution to journalArticle

McWilliams, RR, Maisonneuve, P, Bamlet, WR, Petersen, GM, Li, D, Risch, HA, Yu, H, Fontham, ETH, Luckett, B, Bosetti, C, Negri, EVL, La Vecchia, C, Talamini, R, De Mesquita, HBB, Bracci, PM, Gallinger, S, Neale, RE & Lowenfels, AB 2016, 'Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis', Pancreas, vol. 45, no. 2, pp. 311-316. https://doi.org/10.1097/MPA.0000000000000392
McWilliams, Robert R. ; Maisonneuve, Patrick ; Bamlet, William R. ; Petersen, Gloria M. ; Li, Donghui ; Risch, Harvey A. ; Yu, Herbert ; Fontham, Elizabeth T H ; Luckett, Brian ; Bosetti, Cristina ; Negri, Eva Vanna Lorenza ; La Vecchia, Carlo ; Talamini, Renato ; De Mesquita, H. Bas Bueno ; Bracci, Paige M. ; Gallinger, Steven ; Neale, Rachel E. ; Lowenfels, Albert B. / Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma : A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis. In: Pancreas. 2016 ; Vol. 45, No. 2. pp. 311-316.
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abstract = "Objectives While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. Methods We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age-and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. Results Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95{\%} confidence interval, 1.21-1.84), and there appeared to be a dose-and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95{\%} confidence interval, 1.17-4.09). Conclusions The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.",
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AU - Bamlet, William R.

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AU - Li, Donghui

AU - Risch, Harvey A.

AU - Yu, Herbert

AU - Fontham, Elizabeth T H

AU - Luckett, Brian

AU - Bosetti, Cristina

AU - Negri, Eva Vanna Lorenza

AU - La Vecchia, Carlo

AU - Talamini, Renato

AU - De Mesquita, H. Bas Bueno

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AU - Gallinger, Steven

AU - Neale, Rachel E.

AU - Lowenfels, Albert B.

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N2 - Objectives While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. Methods We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age-and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. Results Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose-and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09). Conclusions The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.

AB - Objectives While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. Methods We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age-and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. Results Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose-and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09). Conclusions The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.

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